Results 51 to 60 of about 771,873 (354)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells

Stem Cell Research & Therapy
Background Platelet transfusion therapy has made a great breakthrough in clinical practice, and the differentiation of human embryonic stem cells (hESCs) to produce functional platelets has become a new potential approach, however, efficient generation ...
Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan   +7 more
doaj   +1 more source

Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study

Platelets
Septic shock is a life-threatening disease worldwide often associated with thrombocytopenia. Platelets play a crucial role in bridging the gap between immunity, coagulation, and endothelial cell activation, potentially influencing the course of the ...
Ruichen Zhang, Haixin Huang, Siwei Lu, Jian Chen, Dandan Pi, Hongxing Dang, Chengjun Liu, Feng Xu, Yue-Qiang Fu   +8 more
doaj   +1 more source

Association of immature platelets with perioperative complications in neurosurgery

Platelets, 2023
Immature platelets are newly formed platelets with an increased prothrombotic potential. This study evaluates whether immature platelets are associated with relevant complications in neurosurgical patients.
Aida Anetsberger, Isabell Bernlochner, Bettina Jungwirth, Manfred Blobner, Bernhard Meyer, Eberhard F Kochs, Dario Bongiovanni, Sebastian Schmid, Clemens Langgartner, Lea Baumgart, Jens Gempt   +10 more
doaj   +1 more source

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]

, 2018
Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F., DeHelian, Daniel, Gupta, Shuchi, Ma, Peisong, Sampietro, Sara, Stalker, Timothy J., Tang, Alan, Tutwiler, Valerie   +7 more
core   +1 more source

Modeling of Polymer Clay Nanocomposite for a Multiscale Approach

, 2008
The mechanical property enhancement of polymer reinforced with nano-thin clay platelets (of high aspect ratio) is associated with a high polymer-filler interfacial area per unit volume.
Arai, Battistella, Becker, Becker, Brougthon, Chen, Chia, Dorigato, Dorigato, Dorigato, Evans, Fermeglia, Fermeglia, Fermeglia, Fiedler, Fischer, Fornes, Frankland, Giannopoulos, Gou, Gou, Green, Guzmàn de Villoria, Ha, Hu, Lange, Lau, Le Pluart, Lee, Li, Liao, Lordi, Luo, Marco Salviato, Marino Quaresimin, Michele Zappalorto, Miyagawa, Mo-lin, Ng, Odegard, Odegard, Odegard, Pipes, Qian, Quaresimin, Ray, Salviato, Scocchi, Thostenson, Thostenson, Toth, Toth, Tsai, VanderHart, Wetzel, Wetzel, Wichmann, Wichmann, Wong, Yokozeki, Yu, Zammarano, Zappalorto, Zappalorto, Zax, Zeng, Zhang, Zhao   +67 more
core   +1 more source

Platinum/ceria/alumina catalysts on microstructures for carbon monoxide conversion [PDF]

, 2005
Platinum/ceria/alumina catalysts have been prepared by a sol–gel method and coated in the microchannels of stainless steel platelets. These catalysts are very active for the water-gas shift reaction between 300 and 400°C.
Alphonse, Pierre, Courty, Matthieu, Germani, G., Mirodatos, Claudine, Schuurman, Yves   +4 more
core   +3 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Appraising non-linear association between pre-diagnostic platelet counts and cancer survival outcomes: observational and genetic analysis

Platelets
Previous studies have reported inconsistent associations between platelet count (PLT) and cancer survival. However, whether there is linear causal effect merits in-depth investigations.
Changtao Li, Junhua Chen, Deqian Han, Chi Shu, Jun Huang, Linru Wei, Haoran Luo, Qingbin Wu, Xin Chen, Yazhou He, Yanhong Zhou   +10 more
doaj   +1 more source

Immature platelets in COVID-19

Platelets, 2023
Platelets play a critical role in immune response. Coronavirus disease 2019 (COVID-19) patients with a severe course often show pathological coagulation parameters including thrombocytopenia, and at the same time the proportion of immature platelets ...
Monika Wolny, Marcus Dittrich, Cornelius Knabbe, Ingvild Birschmann   +3 more
doaj   +1 more source