Results 51 to 60 of about 790,517 (360)

Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells

Stem Cell Research & Therapy
Background Platelet transfusion therapy has made a great breakthrough in clinical practice, and the differentiation of human embryonic stem cells (hESCs) to produce functional platelets has become a new potential approach, however, efficient generation ...
Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan   +7 more
doaj   +1 more source

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

Platelets, 2023
Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch   +3 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Bulk and wetting phenomena in a colloidal mixture of hard spheres and platelets

, 2004
Density functional theory is used to study binary colloidal fluids consisting of hard spheres and thin platelets in their bulk and near a planar hard wall.
L. Harnau, S. Dietrich, W. C. K. Poon, W. Helfrich   +3 more
core   +1 more source

Platinum/ceria/alumina catalysts on microstructures for carbon monoxide conversion [PDF]

, 2005
Platinum/ceria/alumina catalysts have been prepared by a sol–gel method and coated in the microchannels of stainless steel platelets. These catalysts are very active for the water-gas shift reaction between 300 and 400°C.
Alphonse, Pierre, Courty, Matthieu, Germani, G., Mirodatos, Claudine, Schuurman, Yves   +4 more
core   +5 more sources

Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study

Platelets
Septic shock is a life-threatening disease worldwide often associated with thrombocytopenia. Platelets play a crucial role in bridging the gap between immunity, coagulation, and endothelial cell activation, potentially influencing the course of the ...
Ruichen Zhang, Haixin Huang, Siwei Lu, Jian Chen, Dandan Pi, Hongxing Dang, Chengjun Liu, Feng Xu, Yue-Qiang Fu   +8 more
doaj   +1 more source

Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease

Platelets, 2023
Clopidogrel combined with aspirin is widely used in coronary artery disease (CAD) patients, while some patients exhibit high platelet activity when receiving the combined treatment. Current environmental and genetic factors could only explain part of the
Xiaolei Hu, Mupeng Li, He Li, Peiyuan Song, Yanjiao Zhang, Gan Zhou, Jie Tang, Liming Peng, Qilin Ma, Xiaoping Chen   +9 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]

, 2018
Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F., DeHelian, Daniel, Gupta, Shuchi, Ma, Peisong, Sampietro, Sara, Stalker, Timothy J., Tang, Alan, Tutwiler, Valerie   +7 more
core   +1 more source

Modeling of Polymer Clay Nanocomposite for a Multiscale Approach

, 2008
The mechanical property enhancement of polymer reinforced with nano-thin clay platelets (of high aspect ratio) is associated with a high polymer-filler interfacial area per unit volume.
Arai, Battistella, Becker, Becker, Brougthon, Chen, Chia, Dorigato, Dorigato, Dorigato, Evans, Fermeglia, Fermeglia, Fermeglia, Fiedler, Fischer, Fornes, Frankland, Giannopoulos, Gou, Gou, Green, Guzmàn de Villoria, Ha, Hu, Lange, Lau, Le Pluart, Lee, Li, Liao, Lordi, Luo, Marco Salviato, Marino Quaresimin, Michele Zappalorto, Miyagawa, Mo-lin, Ng, Odegard, Odegard, Odegard, Pipes, Qian, Quaresimin, Ray, Salviato, Scocchi, Thostenson, Thostenson, Toth, Toth, Tsai, VanderHart, Wetzel, Wetzel, Wichmann, Wichmann, Wong, Yokozeki, Yu, Zammarano, Zappalorto, Zappalorto, Zax, Zeng, Zhang, Zhao   +67 more
core   +1 more source