Results 61 to 70 of about 432,603 (317)

Effects of platelet-rich fibrin produced by three centrifugation protocols on bone neoformation in defects created in rat calvaria

Platelets, 2023
This study evaluated the potential of Leukocyte-platelet-rich fibrin (L-PRF; fixed angle centrifugation protocol), Advanced-platelet-rich fibrin (A-PRF; low-speed fixed angle centrifugation protocol), and Horizontal-platelet-rich fibrin (H-PRF ...
Débora de Souza Ferreira Sávio, Lucia Moitrel Pequeno da Silva, Gabriel Guerra David Reis, Ricardo Junior Denardi, Natacha Malu Miranda da Costa, Flávia Aparecida Chaves Furlaneto, Sérgio Luís Scombatti de Souza, Carlos Fernando de Almeida Barros Mourão, Richard J. Miron, Roberta Okamoto, Michel Reis Messora   +10 more
doaj   +1 more source

Investigating GABA and its function in platelets as compared to neurons

, 2009
We have recently suggested that platelets could be used as a model for neuronal receptors. In this paper we have investigated γ-aminobutyric acid (GABA) metabolism and GABA receptors in platelets and in cultured neurons to see whether platelets' GABA ...
Kaneez, FS, Saeed, SA
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets

Platelets
Receptor-induced tyrosine phosphorylation of spleen tyrosine kinase (Syk) has been studied extensively in hematopoietic cells. Metabolic mapping and high-resolution mass spectrometry, however, indicate that one of the most frequently detected ...
Carol Dangelmaier, Hymavathi Reddy Vari, Dhruv N Vajipayajula, Manal Elzoheiry, Monica Wright, Ashvin Iyer, Alexander Y Tsygankov, Satya P Kunapuli   +7 more
doaj   +1 more source

Neonatal platelet physiology and implications for transfusion

Platelets, 2022
The neonatal hemostatic system is different from that of adults. The differences in levels of procoagulant and anticoagulant factors and the evolving equilibrium in secondary hemostasis during the transition from fetal/neonatal life to infancy, childhood,
Francisca Ferrer-Marín, Martha Sola-Visner   +1 more
doaj   +1 more source

The phenotype of cryopreserved platelets influences the formation of platelet-leukocyte aggregates in an in vitro model. [PDF]

Cryopreservation significantly alters the phenotype of platelets; generating distinct subpopulations, which may influence the formation of platelet leukocyte aggregates (PLA). PLAs are immunomodulatory and have been associated with transfusion-associated
Marks, DC, Winskel-Wood, B, Padula, MP, Johnson, L   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Exploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Platelets
ST-segment elevation myocardial infarction (STEMI) is usually caused by a ruptured atherosclerotic plaque, with subsequent thrombus formation. Platelet inhibition and primary percutaneous coronary intervention (PCI) are essential treatments.
Menikae K. Heenkenda, Erik Träff, Tomas L. Lindahl, Dimitrios Venetsanos, Joakim Alfredsson   +4 more
doaj   +1 more source

Frozen and cold-stored platelets: reconsidered platelet products

Platelets, 2022
Platelet transfusion, both prophylactic and therapeutic, is a key element in modern medicine. Currently, the standard platelet product for clinical use is platelet concentrates at room temperature (20–24°C) under gentle agitation.
Teresa Jimenez-Marco, Azucena Castrillo, Fernando Hierro-Riu, Vicente Vicente, José Rivera   +4 more
doaj   +1 more source

Acidic preparations of lysed platelets upregulate proliferative pathways in osteoblast-like cells as demonstrated by genome-wide microarray analysis

, 2011
latelets contain numerous growth factors essential for wound and fracture healing. We investigated the gene expression in human osteoblast-like cells stimulated with lysed platelets prepared in acidic, neutral, or alkaline buffers.
Söderström, Mats,, Magnusson, Per, Kalén, Anders,, Per Magnusson, Anders Kalén, Ansell, Anna, Linder, Cecilia, Kalén, Anders, Anna Ansell, Söderström, Mats, Linder, Cecilia,, Ola Wahlström, Magnusson, Per,, Cecilia Halling Linder, Ansell, Anna,, Wahlström, Ola, Mats Söderström, Wahlström, Ola,   +17 more
core   +1 more source