Results 71 to 80 of about 463,872 (313)

Time- and pH-dependent release of PDGF and TGF-ß from platelets in vitro

, 2003
We studied the spontaneous and thrombin-induced activation of platelets and their release of platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) at different pH values. Platelet activation was assayed with anti-bodies against P-
Liu, Yawei,, Kalén, Anders,, Risto, Olof,, Wahlström, Ola,   +3 more
core   +1 more source

ALB–PRF facilitates chondrogenesis by promoting chondrocytes migration, proliferation and differentiation

Platelets
Cartilage injury is common in orthopedics and cartilage tissue engineering provides a therapeutic direction for cartilage regeneration. Albumin (ALB)–platelet-rich fibrin (PRF) is speculated to be an ideal natural scaffold material for cartilage tissue ...
Lijuan Zeng, Jun Zeng, Jianfeng He, Yang Zhou, Yongqi Li, Chengwei Li, Zhiyan Lin, Guangwei Chen, Huilin Wu, Libin Zhou   +9 more
doaj   +1 more source

Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects

Platelets, 2022
We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ...
Oscar Salva, Roxana Alasino, Celia Giller, Julieta Borello, Alexis Doresky, Galia Karayan, Dante Beltramo   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The phenotype of cryopreserved platelets influences the formation of platelet-leukocyte aggregates in an in vitro model. [PDF]

Cryopreservation significantly alters the phenotype of platelets; generating distinct subpopulations, which may influence the formation of platelet leukocyte aggregates (PLA). PLAs are immunomodulatory and have been associated with transfusion-associated
Marks, DC, Winskel-Wood, B, Padula, MP, Johnson, L   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

GAMMA-GLUTAMYL-TRANSFERASE ACTIVITY IN HUMAN PLATELETS - QUANTIFICATION OF ACTIVITY, ISOENZYME CHARACTERIZATION AND POTENTIAL CLINICAL RELEVANCE

, 1995
Gamma-glutamyltransferase (GGT) activity in human platelet sonicates was 13.6 u/g of protein (range: 7.9-25.0) in 13 healthy, non-smoking, female volunteers; corresponding values in 16 males were: 20.3 (10.1-26.0), These values differed significantly (p =
NWOSE, OM, GURDOL, F, MIKHAILIDIS, DP
core   +1 more source

Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances [PDF]

, 2015
Exocytosis of lysosomal contents from platelets has been speculated to participate in clearance of thrombi and vessel wall remodelling. The mechanisms that regulate lysosomal exocytosis in platelets are, however, still unclear.
Eva G. Lindström (808840), Svensson Holm, Ann-Charlotte,, Öllinger, Karin,, Öllinger, Karin, Ann-Charlotte B. Svensson Holm (808838), Holm, Ann-Charlotte B. Svensson,, Magnus Grenegård (808841), Sodergren, Anna L.,, Anna L. Södergren (808837), Svensson Holm, Ann-Charlotte, Grenegård, Magnus, Karin Öllinger (118603), Lindström, Eva,, Lindström, Eva G.,, Ramström, Sofia,, Södergren, Anna, Ramström, Sofia, Södergren, Anna,, Lindström, Eva, Sofia Ramström (808839), Grenegård, Magnus,   +20 more
core   +1 more source

Severe thrombocytopenia and intracranial hemorrhage in a newborn with Noonan syndrome and neonatal alloimmune thrombocytopenia

Platelets, 2022
Noonan syndrome (NS) is a genetic disorder with distinctive physical features and often multiple organ involvement. Bleeding disorders are reported in over half of patients with NS, including thrombocytopenia and platelet dysfunction. Neonatal alloimmune
Rebecca Carter, Anna-Kaisa Niemi
doaj   +1 more source

Blood platelet kinetics and platelet transfusion [PDF]

Journal of Clinical Investigation, 2013
The discovery of citrate anticoagulant in the 1920s and the development of plastic packs for blood collection in the 1960s laid the groundwork for platelet transfusion therapy on a scale not previously possible. A major limitation, however, was the finding that platelet concentrates prepared from blood anticoagulated with citrate were unsuitable for ...
openaire   +2 more sources