Results 41 to 50 of about 190,247 (255)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Social Media + Society, 2019 This study investigates cross-platform differences in social media by analyzing the contending candidates who represent different political ideology during the 2016 presidential election.
Abdulsamad Sahly +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Evaluation of Seismic Performance of Reinforced Concrete Frame Structures in the Context of Big Data
Complexity, 2019 In the era of big data, the efficient use of idle data in reinforced concrete structures has become a key issue in optimizing seismic performance evaluation methods for building structures.
Du Guangqian, Zheng Meng, Wang Shijie
doaj +1 more source
Speed Estimation of Multiple Moving Objects from a Moving UAV Platform
ISPRS International Journal of Geo-Information, 2019 Speed detection of a moving object using an optical camera has always been an important subject to study in computer vision. This is one of the key components to address in many application areas, such as transportation systems, military and naval ...
Debojit Biswas +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Development of Hydraulic Control System for Multi-Functional Drilling Test Platform
Shiyou jixie, 2023 Over recent years,building a surface drilling test platform to simulate the actual downhole conditions has become an important approach for verifying and improving new technology,new process and new tools of drilling.The design and development of the ...
Wang Xingming +5 more
doaj
Medžiagotyra, 2015 Materials of satellite integration truss frame are required to withstand temperature that range from about – 250 °C ~ + 150 °C. In order to reduce structural components deformation caused by such temperature change, material of truss frame mostly adopts
Xusheng ZHU, Lianyu ZHENG, Fenglong YANG
doaj +1 more source
Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design
Angewandte ChemieAbstract Chemists continue to develop strategies that leverage abundant feedstocks to accelerate the production of medicines, agrochemicals, and materials. Oligoheterocycles are a broad class of molecules that span these disciplines. Cross‐coupling strategies are commonly used to assemble oligoheterocycles; however, these methods can ...
Kane A. C. Bastick +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source