Results 101 to 110 of about 459,220 (352)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Improving supply chain management in construction: what can be learned from the aerospace industry? [PDF]

, 2003
In order to provide for controllable delivery, reliable lead times and efficient customer response, lean manufacturing and platform assembly practices play an important role in supply chains in the aerospace industry.
Voordijk, H., Vrijhoef, R.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Regulating Disinformation and Ideological Entrepreneurs: An Exploratory Research on the Digital Services Act Implementation

Media and Communication
The introduction of the Digital Services Act (DSA) by the EU marks a fundamental step in the governance of social media platforms, by outlining content-moderation guidelines aimed at preventing disinformation and the systemic risks related to the ...
Sara Monaci, Simone Persico
doaj   +1 more source

Current Services In Cloud Computing: A Survey

, 2013
Due to the fast development of the Cloud Computing technologies, the rapid increase of cloud services are became very remarkable. The fact of integration of these services with many of the modern enterprises cannot be ignored.
El-Nasr, Mohamad Abou, Mosbah, Mohamed Magdy, Soliman, Hany   +2 more
core   +1 more source

Governance of visibility platform

, 2021
A real-time transportation visibility platform develops its network by adding successive complementors. The governance mechanism benefits the platform owner the most and creates asymmetries among platform members. These asymmetries trigger coopetition tensions between governance costs and co-created value, autonomy, and control.
openaire   +1 more source

‘The giving layer of the internet’: A critical history of GoFundMe's reputation management, platform governance, and communication strategies in capturing peer‐to‐peer and charitable giving markets [PDF]

, 2022
Matthew Wade
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Empowered or Constrained in Platform Governance? An Analysis of Twitter Users’ Responses to Elon Musk’s Takeover

Social Media + Society
Centering on social media’s public- and profit-oriented nature, this study theorizes how social media users are empowered and constrained when participating in platform governance through user-initiated expressions on platforms.
Rui Wang, Yini Zhang, Jiyoun Suk, Sara Holland Levin   +3 more
doaj   +1 more source

Pattern Recognition: Industry seeking regulation – the case of crowdfunding. Bruges Political Research Papers 79/2020 [PDF]

, 2020
At first it seems counterintuitive that an industry would seek regulation over itself, but from the point of view of crowdfunding, it was a logical step.
Ambrus, Eva
core