Results 91 to 100 of about 459,220 (352)

Methodological Guide to Co-design Climate-smart Options with Family Farmers [PDF]

, 2018
Climate-smart agriculture (CSA) seeks to improve productivity for the achievement of food security (pillar 1: Productivity), to develop a better ability to adapt (pillar 2: Adaptation), and to limit greenhouse gas emissions (pillar 3: Mitigation ...
Acosta-Alba, Ivonne, Andrieu, Nadine, Chia, Eduardo, Howland, Fanny, Le Coq, Jean-François, Osorio, A.M.   +5 more
core   +1 more source

FixMyStreet Brussels: Socio-Demographic Inequality in Crowdsourced Civic Participation

, 2017
FixMyStreet (FMS) is a web-based civic participation platform that allows inhabitants to report environmental defects like potholes and damaged pavements to the government. In this paper, we examine the use of FMS in Brussels, the capital city of Belgium.
Chua, Alvin, Moere, Andrew Vande, Pak, Burak   +2 more
core   +1 more source

Governance of adaptive platform trials

Wellcome Open Research, 2023
Adaptive Clinical Trials (ACT) differ from conventional clinical trials because they permit continual modifications to key components of trial design during the trial. ACTs have grown in prevalence in recent years, with Adaptive Platform Trials (APTs), in particular, having demonstrated their significant scientific, clinical, and public health utility ...
openaire   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The existential stakes of platform governance: a critical literature review. [PDF]

Open Res Eur, 2021
Papaevangelou C.
europepmc   +1 more source

African small and medium enterprises, networks, and manufacturing performance [PDF]

This paper examines the role of private support institutions in determining small and medium enterprise (SME) growth and performance in Sub-Saharan Africa (SSA).
Biggs, Tyler, Shah, Manju Kedia
core  

When Platforms Act Opportunistically: The Ethics of Platform Governance

, 2022
Kirsten Martin, Hong Guo, Robert F. Easley   +2 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Governing digital societies: Private platforms, public values

Computer Law & Security Review, 2020
Online digital platforms have deeply penetrated every sector in society, disrupting markets, labor relations and institutions, while transforming social and civic practices. Moreover, platform dynamics have affected the very core of democratic processes and political communication.
openaire   +2 more sources