Results 71 to 80 of about 3,191,151 (256)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Corporate governance principles and recommendations (3rd ed.) [PDF]
, 2014 Following a comprehensive review in 2012-13, the 21 members of the ASX Corporate Governance Council (“Council”) agreed that it was an appropriate time to issue a third edition of the Principles and Recommendations.
ASX Corporate Governance Council
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Platforms as Epistemic Devices: The Production and Contestation of Knowledge in Platform Societies
PlatformsSocial research now depends on environments that commercial platforms own and continually redesign. This article argues that platforms operate not only as objects of inquiry and infrastructures for data production but also as epistemic devices that shape
Suania Acampa
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in Public HealthIntroductionInefficient matching between medical experts and health advice seekers remains a challenge in online health communities. This study constructs the Recommendation Model with Profile Enhancement (RMPE), which integrates service quality and user
Yan Shen, Hui Long, Qian Wang
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
, 2021 The continuous growth of online platforms is accompanied by the increasing use of automation for providing and utilizing their services. One form of automation, which is increasingly (ab)used by platform users for a multitude of tasks (e.g., content ...
Makhortykh, Mykola +5 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Studying Platform Governance of Hate Speech
The study of platform governance involves the analysis of a multitude of ‘infinitesimal techniques’ that platforms employ to influence our lives and entails comprehending the knowledge and intentions underlying these techniques.
Viejo Otero, Paloma
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