Results 111 to 120 of about 459,220 (352)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Pro-democracy platform advocacy: Resisting Big Tech-mediated authoritarianism in Southeast Asia [version 2; peer review: 2 approved]

open access: yesOpen Research Europe
Background Global platforms, such as Meta, YouTube, X (formerly Twitter), TikTok, and Telegram, have faced widespread criticisms for facilitating authoritarian repression of dissident voices, especially in the Global South.
Tuwanont Phattharathanasut   +4 more
doaj   +1 more source

Whorephobia on Dating Platforms: Ethical Platform Governance

open access: yesPhilosophy & Technology
Abstract Dating platforms generally prohibit commercial sex on their platforms and warn users that they will be deplatformed if they engage in the sex market on them. Sex workers, however, report experiencing deplatforming even when they are seeking personal, non-commercial relationships on dating platforms, which raises complaints of
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The Political Economy of Web3 Platformization: Innovation Systems, Reaching the Moon, Governing the Ghetto

open access: yesDigital
This article investigates how Web3 decentralization unfolds in practice and asks two guiding questions: (i) How democratic are decentralized governance systems in practice?
Igor Calzada
doaj   +1 more source

Understanding smart contracts as a new option in transaction cost economics [PDF]

open access: yes, 2019
Among different concepts associated with the term blockchain, smart contracts have been a prominent one, especially popularized by the Ethereum platform. In this study, we unpack this concept within the framework of Transaction Cost Economics (TCE). This
Halaburda, Hanna   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The Governance and Regulation of Video Platforms in Iran: From the Conflict over the Regulatory Authority to Content Moderation (Case Study: Aparat)

open access: yesحقوق فناوریهای نوین
The purpose of this paper is to discuss discusses the legal and technological challenges and disputes about the governance and regulation of user-generated video platforms. In this paper, by focusingon the Aparat video service, we will show how the issue
Hossein Hassani
doaj   +1 more source

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