Results 41 to 50 of about 1,248,661 (307)

Answering impossible questions: Content governance in an age of disinformation

Harvard Kennedy School Misinformation Review, 2020
The governance of online platforms has unfolded across three eras – the era of Rights (which stretched from the early 1990s to about 2010), the era of Public Health (from 2010 through the present), and the era of Process (of which we are now seeing the ...
John Bowers, Jonathan Zittrain
doaj   +1 more source

Representation, searching and discovery of patterns of bases in complex RNA structures [PDF]

We describe a graph theoretic method designed to perform efficient searches for substructural patterns in nucleic acid structural coordinate databases using a simplified vectorial representation.
Artymiuk, P.J., Harrison, A-M., South, D.R., Willett, P.   +3 more
core   +1 more source

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice [PDF]

, 2015
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC.
Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Cauwels, Anje, De Cauwer, Lode, Decaluwé, Kelly, Delanghe, Joris, Geschka, Sandra, Hochepied, Tino, Karas, Richard H, Rogge, Elke, Sips, Patrick, Stasch, Johannes-Peter, Tainsh, Robert E, Thoonen, Robrecht, Van de Voorde, Johan, Voet, Sofie, Vuylsteke, Marnik   +17 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Multi-locus CRISPRi targeting with a single truncated guide RNA

Nature Communications
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here,
Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm   +14 more
doaj   +1 more source

Misleading tobacco content is on the rise on YouTube

Harvard Kennedy School Misinformation Review, 2020
A content analysis of popular videos on YouTube containing tobacco-relevant material revealed five categories of misleading content about tobacco use in 2013. A re-examination in 2019 of the most heavily viewed exemplars of these categories identified in
Daniel Romer, Zachary Reese, Patrick E. Jamieson   +2 more
doaj   +1 more source

A Call for Change: The Evolution of the Modern Documentary from Informative Media to Persuasive Platform [PDF]

, 2011
In the past several years, new documentaries have begun to evolve from informative media to persuasive platform as a result of changing cultural contexts and ideologies.
England, Valerie
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Emergence of Platform Regulation in the UK

Weizenbaum Journal of the Digital Society, 2022
Online platforms have emerged as a new kind of regulatory object. In this article, we empirically map the emergence of the field of platform regulation in one country: the United Kingdom (UK).
Martin Kretschmer, Ula Furgał, Philip Schlesinger   +2 more
doaj   +1 more source

Can self-regulation save digital platforms?

Industrial and Corporate Change, 2021
AbstractThis article explores some of the critical challenges facing self-regulation and the regulatory environment for digital platforms. We examine several historical examples of firms and industries that attempted self-regulation before the Internet.
Michael A Cusumano, Annabelle Gawer, David B Yoffie   +2 more
openaire   +1 more source