Results 51 to 60 of about 5,639,155 (335)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multi-locus CRISPRi targeting with a single truncated guide RNA

Nature Communications
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here,
Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm   +14 more
doaj   +1 more source

Answering impossible questions: Content governance in an age of disinformation

Harvard Kennedy School Misinformation Review, 2020
The governance of online platforms has unfolded across three eras – the era of Rights (which stretched from the early 1990s to about 2010), the era of Public Health (from 2010 through the present), and the era of Process (of which we are now seeing the ...
John Bowers, Jonathan Zittrain
doaj   +1 more source

PERSIST platform provides programmable RNA regulation using CRISPR endoRNases

Nature Communications, 2022
Regulated transgene expression is an integral component of gene therapies, cell therapies and biomanufacturing. However, transcription factor-based regulation, upon which most applications are based, suffers from complications such as epigenetic ...
B. DiAndreth, Noreen Wauford, E. Hu, Sebastian Palacios, Ron Weiss   +4 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Misleading tobacco content is on the rise on YouTube

Harvard Kennedy School Misinformation Review, 2020
A content analysis of popular videos on YouTube containing tobacco-relevant material revealed five categories of misleading content about tobacco use in 2013. A re-examination in 2019 of the most heavily viewed exemplars of these categories identified in
Daniel Romer, Zachary Reese, Patrick E. Jamieson   +2 more
doaj   +1 more source

Sharing on platforms: Reducing perceived risk for peer‐to‐peer platform consumers through trust‐building and regulation

Journal of Consumer Behaviour, 2022
Sharing a flat with strangers is no longer hypothetical but well accepted by many consumers who participate in peer‐to‐peer (P2P) services. Online P2P sharing platforms act as intermediaries between providers and consumers who do not know each other ...
Sarah Marth, Barbara Hartl, E. Penz
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Unveiling ‘Algorithm Governance’

Weizenbaum Journal of the Digital Society
Research on platform work has primarily focused on analyzing how algorithmic management influences working conditions by empowering platforms to govern digitally-delivered services.
Valeria Pulignano
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source