Results 91 to 100 of about 928,606 (352)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ultralow-loading platinum-cobalt fuel cell catalysts derived from imidazolate frameworks

Science, 2018
Combine and conquer Platinum (Pt)–group metals, which are scarce and expensive, are used for the demanding oxygen reduction reaction (ORR) in hydrogen fuel cells.
L. Chong, J. Wen, J. Kubal, F. Sen, J. Zou, J. Greeley, Maria K. Y. Chan, H. Barkholtz, W. Ding, Di-Jia Liu   +9 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Conflict between work and nonwork roles of employees in the mining industry: Prevalence and differences between demographic groups

SA Journal of Human Resource Management, 2011
Orientation: International researchers have increasingly recognised the interaction between work and nonwork roles as an interesting and important topic.
Betsie Steyl, Eileen Koekemoer
doaj   +1 more source

Hydrosilylation of 1-alkenes with dichlorosilane [PDF]

, 1995
Symmetrically and unsymmetrically substituted diorganodichlorosilanes have been prepared by hydrosilylation with dichlorosilane using two different platinum catalysts, i.e., hexachloroplatinic acid (Speier's catalyst) and a platinum ...
Frey, Holger, Klok, Harm-Anton, Möller, Martin, Out, Gerardus J.J., Schwegler, Leonore   +4 more
core   +4 more sources

On the Controlled Loading of Single Platinum Atoms as a Co‐Catalyst on TiO2 Anatase for Optimized Photocatalytic H2 Generation

Advances in Materials, 2020
Single‐atom (SA) catalysis is a novel frontline in the catalysis field due to the often drastically enhanced specific activity and selectivity of many catalytic reactions.
S. Hejazi, S. Mohajernia, B. Osuagwu, G. Zoppellaro, Pavlína Andrýsková, Ondřej Tomanec, Š. Kment, R. Zbořil, P. Schmuki   +8 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Microstructural evolution and nanoindentation creep behavior in a PdAgCuAuPtZn multi-principal elements alloy

Journal of Materials Research and Technology
The precious metal based multi-principal elements alloy (MPEA) PdAgCuAuPtZn is mainly used in electrical contact applications, as a new type of multi-component alloy.
Xuan Zhou, Hualong Ge, Shunmeng Zhang, Li Fu, Zhiwei Xia, Junjie He, Kai Xiong, Jun Cheng, Yi Liu, Lihua Ma, Quan Fu, Zhi Xiong, Yong Mao   +12 more
doaj   +1 more source

Synthesis and Characterization of Nanoscale Tungsten Particles with Hollow Superstructure Using Spray Drying Combined with Calcination Process

Nanoscale Research Letters, 2019
Nanoscale tungsten (W) powder is used in some special materials. In this study, a hollow superstructure W powder consisting of nanoparticles was synthesized by spray drying combined with two-step calcination from commercial (NH4)6W7O24·6H2O.
Panchao Zhao, Wei Yi, Qigao Cao, Bosheng Zhang, Kunkun Chen, Rui Dang, Jialin Chen   +6 more
doaj   +1 more source