Results 71 to 80 of about 928,606 (352)

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. [PDF]

, 2019
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence.
Anderson, Kristen, Barrie, Allison M, Bean, Lisa M, Chen, Xiao Lei, Connolly, Denise C, Cordasco, Edward A, Diaz Osterman, Carlos J, Fisch, Kathleen M, Fu, Guo, Győrffy, Balázs, Heino, Jyrki, Jean, Christine, Jiang, Shulin, Kleinschmidt, Elizabeth G, Kolev, Vihren N, Li, Jian, Mark, Adam M, McHale, Michael T, Molinolo, Alfredo, Ojalill, Marjaana, Ozmadenci, Duygu, Pachter, Jonathan A, Rappu, Pekka, Schlaepfer, David D, Stupack, Dwayne G, Sulzmaier, Florian J, Tancioni, Isabelle, Taylor, Kristin N, Uryu, Sean, Weaver, David T, Xu, Guorong   +30 more
core   +1 more source

Issues Relevant to C-H Activation at Platinum(II): Comparative Studies between Cationic, Zwitterionic, and Neutral Platinum(II) Compounds in Benzene Solution [PDF]

, 2004
Cationic late metal systems are being highly scrutinized due to their propensity to mediate so-called electrophilic C-H activation reactions. This contribution compares the reactivity of highly reactive cationic platinum(II) systems with structurally
Betley, Theodore A., Peters, Jonas C., Thomas, Christine M., Thomas, J. Christopher   +3 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Platinum/ceria/alumina catalysts on microstructures for carbon monoxide conversion [PDF]

, 2005
Platinum/ceria/alumina catalysts have been prepared by a sol–gel method and coated in the microchannels of stainless steel platelets. These catalysts are very active for the water-gas shift reaction between 300 and 400°C.
Alphonse, Pierre, Courty, Matthieu, Germani, G., Mirodatos, Claudine, Schuurman, Yves   +4 more
core   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization. [PDF]

, 2016
RRx-001, an experimental systemically non-toxic epi-immunotherapeutic agent, which potentiates the resensitization of resistant cancer cells to formerly effective therapies, is under active investigation in several clinical trials that are based on ...
Brzezniak, Christina, Cabrales, Pedro, Caroen, Scott Z, Carter, Corey A, Degesys, Aiste, Jenkins, John, Oronsky, Bryan T, Reid, Tony, Scicinski, Jan J   +8 more
core   +3 more sources

Platinum single-atom and cluster catalysis of the hydrogen evolution reaction

Nature Communications, 2016
Platinum-based catalysts have been considered the most effective electrocatalysts for the hydrogen evolution reaction in water splitting. However, platinum utilization in these electrocatalysts is extremely low, as the active sites are only located on ...
N. Cheng, S. Stambula, Da Wang, M. Banis, Jian Liu, Adam Riese, B. Xiao, Ruying Li, T. Sham, Li‐Min Liu, G. Botton, X. Sun   +11 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Single platinum atoms embedded in nanoporous cobalt selenide as electrocatalyst for accelerating hydrogen evolution reaction

Nature Communications, 2019
Designing efficient electrocatalysts for hydrogen evolution reaction is significant for renewable and sustainable energy conversion. Here, we report single-atom platinum decorated nanoporous Co0.85Se (Pt/np-Co0.85Se) as efficient electrocatalysts for ...
Kang Jiang, Boyang Liu, M. Luo, S. Ning, Ming Peng, Yang Zhao, Ying-Rui Lu, T. Chan, F. D. de Groot, Yongwen Tan   +9 more
semanticscholar   +1 more source

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Nature Communications, 2020
Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by increased ATR-CHK1 activity and sensitivity to ATR inhibition (ATRi). However, PARPi-
Hyoung Kim, Haineng Xu, E. George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, S. Medvedev, Yasuto Kinose, Kyle M. Devins, P. Verma, Kévin Ly, Yifan Wang, R. Greenberg, L. Schwartz, N. Johnson, R. Scharpf, G. Mills, Rugang Zhang, V. Velculescu, E. Brown, F. Simpkins   +20 more
semanticscholar   +1 more source