Results 111 to 120 of about 5,331,821 (317)

2025 Position statement on active outdoor play

International Journal of Behavioral Nutrition and Physical Activity
Background In 2015, the Position Statement on Active Outdoor Play was released in Canada, emphasizing the critical role of active outdoor play—with its risks—in fostering children’s healthy development.
Eun-Young Lee, Louise de Lannoy, Yeong-Bae Kim, Apoorva Rathod, Maeghan E. James, Olivia Lopes, Brianna Nasrallah, Anujah Thankarajah, Dina Adjei-Boadi, Maria Isabel Amando de Barros, Scott Duncan, Robyn Monro Miller, Lærke Mygind, Leigh M. Vanderloo, Po-Yu Wang, Mark S. Tremblay, AOP10 Steering Committee Group   +16 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Play in Chinese kindergartens : teachers' perceptions and practices [PDF]

Play is widely recognized as a natural ability and fundamental right of children. In educational settings, the idea of integrating play into early childhood education to promote children’s learning and development has been continually advocated by ...
Yang, Yanjuan
core  

Community Play Co-ordinator job description [PDF]

Job description for a paid worker for the Cricklewood Community Play Association (CCPA)
Cricklewood Community Play Association, CCPA, Cricklewood Community Play Association   +1 more
core   +2 more sources

The relationship of adults’ memories of their childhood play with their children’s life satisfaction and attitude to the game of their children

Современное дошкольное образование
Background. The value of the children’s game lies in its developing potential, which determines the need to support it by adults, especially parents. Research indicates that such support contributes to better developmental outcomes in children. Moreover,
Irina A. Ryabkova, Victoria M. Chernaya, Irina A. Kan   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

To Play or Not to Play [PDF]

Foot & Ankle International, 1998
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source