Results 121 to 130 of about 5,331,821 (317)

Designing for social interaction through physical play, movement and learning

, 2008
This paper reports on two related but different developments in relation to designing for social interaction. It intends to compare and link together both a four years old international collaborative industrial design and manufacturing studio project ...
Novoa, Mauricio (R13411)
core  

Organization of project activities in preschool educational institutions on the example of the Golden Pedagogical Ring project

Современное дошкольное образование
Background. Project activities in kindergarten are an urgent area that meets modern educational standards and contributes to the comprehensive development of children.
Larisa L. Shevchenko, Maria V. Stepanova
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The effects of an enriched environment and teacher intervention on the dramatic and sociodramatic play of children [PDF]

, 2007
This study examined the effects of an enriched environment and teacher intervention on the dramatic and sociodramatic play of four to five year old children in Singapore.
Lu Soo Ai, Theresa
core  

Human-centered design and early evaluation of an interface for mobile-manipulator-mediated pediatric occupational therapy

Frontiers in Robotics and AI
Assistive mobile robots can play an important role in supporting individuals with disabilities. While the field of robot control interfaces for individuals with disabilities is growing, there is little work done on such systems for children end users ...
Rafael Morales Mayoral, Samuel W. Logan, Naomi T. Fitter   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Sociodramatic play of kindergarten and first grade children.

, 1979
The purpose of this study was to examine the effects of modeling on the sociodramatic play of kindergarten and first grade subjects enrolled in an elementary school receiving Title I funding.
Weddle, Charles D.
core  

Handbook of Play, Therapeutic Play, and Play Therapy

Creative Arts in Education and Therapy, 2022
This paper reviews the title: Jennings, S., & Holmwood, C. (Eds). Routledge International Handbook of Play, Therapeutic Play and Play Therapy. Taylor & Francis. https://bookshelf.vitalsource.com/books/9781000228656. This International Handbook is a new, unique, timely examination of play, therapeutic play, play in therapy, and play therapy with ...
openaire   +1 more source