Results 91 to 100 of about 8,044,780 (313)

Characteristics of Role Substitution in Preschooler’s Play with Different Materials Psychological-Educational Studies

Психолого-педагогические исследования, 2018
The paper compares the role play of preschool children from 3 to 7 years with two different types of play material: play clothes and open-ended materials.
Ryabkova I.A.
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The hot stove effect in repeated-play decision making under ambiguity [PDF]

The ''hot stove effect'' has been studied for repeated-play decision making under uncertainty (also referred to as experience-based decision making) in which the decision makers repeatedly face the Allais-type binary choice problems, and have to learn ...
Fujikawa, Takemi
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

MMORPGs and Their Effect on Players [PDF]

, 2017
The purpose of this essay is to explore the popularity and effects of video games in the MMORPG genre. Games and play have been a part of human culture for an exceptionally long time, and in the recent decades video games have a become a large medium to ...
Manocha, Udit
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dendritic cell subsets in the intestinal lamina propria: ontogeny and function [PDF]

, 2013
The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in ...
Agace, Agace, Agace, Aliberti, Anjuere, Annacker, Bachem, Bachem, Bain, Banchereau, Bedoui, Bogunovic, Carter, Cebula, Cerovic, Chervonsky, Coombes, Crozat, Cruickshank, del Rio, del Rio, Denning, Diehl, Edelson, Edelson, Farache, Forster, Fujimoto, Ginhoux, Greter, Hadis, Halle, Hammerschmidt, Haniffa, Hildner, Hoshi, Ichikawa, Iwata, Jackson, Jaensson, Jaensson-Gyllenback, Jang, Johansson-Lindbom, Johansson-Lindbom, Jones, Jongbloed, Kinnebrew, Kobayashi, Kusunoki, Lewis, Liu, Macpherson, Maynard, McDole, Merad, Miller, Milling, Molenaar, Mucida, Naik, Naik, Niess, Onai, Persson, Poulin, Poulin, Rescigno, Rivollier, Sathaliyawala, Schlitzer, Schulz, Scott, Siddiqui, Sun, Svensson, Tamoutounour, Travis, Uematsu, Uematsu, Vallon-Eberhard, Varol, Vremec, Weiss, Worbs, Wu, Zeng, Zhan, Zigmond   +87 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Rethinking Gamification within a Genealogy of Governmental Discourses

Open Philosophy
The aim of this article is to explore the benefits of a genealogical approach of gamification in our understanding of government and its history. Since gamification is as much a discourse on the game as a project of governmentality, to make its genealogy
Nony Justin
doaj   +1 more source

Whodology: Encountering Doctor Who fan fiction through the portals of play studies and ludology

Transformative Works and Cultures, 2011
The fan fiction that is inspired by the textual world of both the original and new series of Doctor Who seems to provide a paratextual world of its own that produces a fascinatingly multidirectional relationship with the narratives that inspire it ...
Charles William Hoge
doaj   +1 more source