Results 81 to 90 of about 210,488 (345)
Control strategy of water supplying system with constant pressure and its implement(恒压供水系统控制策略及其实现)
Zhejiang Daxue xuebao. Lixue ban, 2002 为了提高大范围变负荷恒压供水系统的控制精度和可靠性,提出了采用多台水泵分级控制、轮流变频的控制策略,同时结合大范围变负荷供水系统的特点对常规PID控制算法作了一些相应的改进;通过基于USS协议的标准驱动产品和PLC的组合,实现系统硬件、软件和通信的设计,从而改进了大范围恒压供水系统的控制品质.
WUXiao-fu(吴肖甫) +2 more
doaj +1 more source
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Advanced Science, EarlyView.Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han +6 more
wiley +1 more source
Development of Automatic Welding System for Offshore Platform Pile Pipe
Journal of Harbin University of Science and Technology, 2017 Twin arc welding system for offshore platform pile pipe with multipoint dual power and a single molten pool is put forward in this paper in order to solve the problems of low producing efficiency and operating inconvenience in complex environment ...
XU Jia-zhong +4 more
doaj +1 more source
Advanced Science, EarlyView.Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang +14 more
wiley +1 more source
PLC Based DC Motor Speed Monitoring and Controlling System
, 2021 Shraddha Nagare +3 more
openalex +1 more source
Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy
Advanced Science, EarlyView.A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen +8 more
wiley +1 more source
Modularity and architecture of PLC-based software for automated production Systems: An analysis in industrial companies [PDF]
, 2017 Birgit Vogel‐Heuser +4 more
openalex +1 more source
F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
Advanced Science, EarlyView.In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source