Results 61 to 70 of about 19,023 (240)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Respiratory Muscle Strength and Exercise Performance in Cystic Fibrosis–A Cross Sectional Study

Frontiers in Pediatrics, 2018
Introduction: Decreased respiratory muscle strength in patients with cystic fibrosis (CF) may cause progressive exercise intolerance during cardiopulmonary exercise testing (CPET), and may contribute to the development of chronic respiratory ...
Aleksandar Sovtic, Aleksandar Sovtic, Predrag Minic, Predrag Minic, Gordana Markovic-Sovtic, Goran Z. Trajkovic, Goran Z. Trajkovic   +6 more
doaj   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study

BMJ Open Respiratory Research, 2020
Introduction Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF).
Matthew Shaw, Thomas Simon FitzMaurice, Paul Stephen McNamara, Dilip Nazareth, Caroline McCann, Ram Bedi, Martin Walshaw   +6 more
doaj   +1 more source

Beware the Meta-Analysis: Is Multiple Set Training Really Better than Single-Set Training for Muscle Hypertrophy? [PDF]

, 2012
While many individuals perform resistance training with the purpose of increasing the size of their muscles, reviews have not clarified a training prescription for optimizing hypertrophy. A 2010 meta-analysis concluded that multiple set training resulted
Fisher, James
core   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Diagnostic accuracy of spirometry in primary care [PDF]

, 2009
Contains fulltext : 80404.pdf (publisher's version ) (Open Access)BACKGROUND: To evaluate the sensitivity, specificity and predictive values of spirometry for the diagnosis of chronic obstructive pulmonary disease (COPD) and asthma in ...
Antonius Schneider, Lena Gindner, Lisa Tilemann, Tjard Schermer, Geert-Jan Dinant, Franz Joachim Meyer, Joachim Szecsenyi, AE Tattersfield, PM Calverley, CJ Murray, National Institute of Health, National Institute of Health, PP Walker, J Buffels, RO Crapo, HA Thiadens, G van den Boom, E Derom, PJ Poels, RS Ledley, GT O'Connor, JA Knottnerus, A Schneider, DL Simel, MR Miller, R Pellegrino, J Wanger, American Association for Respiratory Care, NM Siafakas, C Vogelmeier, PH Quanjer, CJ Hunter, A James, M Perpina, EB Wilson, DG Altman, RE Dales, RE Dales, JJ den Otter, N Kunzli, SA Kharitonov, A Schneider, P Whiting, TR Schermer, I Cerveri, M Miravitlles, TR Schermer, N Chavannes   +47 more
core   +2 more sources

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation

International Journal of COPD, 2017
Gabor Tajti,1,2 Rudolf Gesztelyi,3 Krisztian Pak,3 Csaba Papp,1 Sandor Keki,4 Magdolna Emma Szilasi,2 Angela Mikaczo,2 Andrea Fodor,2 Maria Szilasi,2 Judit Zsuga1 1Department of Health Systems Management and Quality Management for Health Care, Faculty ...
Tajti G, Gesztelyi R, Pak K, Papp C, Keki S, Szilasi ME, Mikaczo A, Fodor A, Szilasi M, Zsuga J   +9 more
doaj  

The Murine Cl-/HCO3- Exchanger Ae3 (Slc4a3) is Not Required for Acid-Base Balance but is Involved in Magnesium Handling by the Kidney

Cellular Physiology and Biochemistry, 2014
Background: The Slc4 family of bicarbonate transporters consists of several members, many of which are highly expressed in the kidney and play an important role in acid-base homeostasis. Among them are Ae1 (Slc4a1) and Ae2 (Slc4a2).
Nicole B. Kampik, Nicole Gehring, Udo Schnitzbauer, J. Christopher Hennings, Christian A. Hübner, Carsten A. Wagner   +5 more
doaj   +1 more source