Results 71 to 80 of about 10,594 (224)

More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease

Arthritis Research & Therapy, 2023
Objective To compare body composition between patients with psoriatic disease (PsD), including cutaneous psoriasis (PsO) and psoriatic arthritis (PsA), and controls, and to explore associations between disease activity and measures of function and ...
Tim Blake, Nicola J. Gullick, Charles E. Hutchinson, Abhir Bhalerao, Sarah Wayte, Andrew Weedall, Thomas M. Barber   +6 more
doaj   +1 more source

Physical Activity Profile of School‐Aged Children Born Very Preterm and Its Association With Sleep

Acta Paediatrica, EarlyView.
ABSTRACT Aim To describe the association between different physical activity and sleep parameters in school‐aged children born very preterm. Methods A cross‐sectional analysis was done in a cohort of 6‐ to 10‐year‐old children born at < 32 weeks' gestation at the Department of Neonatology, University of Tübingen, Germany.
Maham Hassan, Saskia Koller, Annkathrin Gies, Axel R. Franz, Johanna Catharina Brückner, Vadim Förster, Christian F. Poets, Christoph Randler, Cornelia Wiechers, Mirja Quante   +9 more
wiley   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Respiratory Muscle Strength and Exercise Performance in Cystic Fibrosis–A Cross Sectional Study

Frontiers in Pediatrics, 2018
Introduction: Decreased respiratory muscle strength in patients with cystic fibrosis (CF) may cause progressive exercise intolerance during cardiopulmonary exercise testing (CPET), and may contribute to the development of chronic respiratory ...
Aleksandar Sovtic, Aleksandar Sovtic, Predrag Minic, Predrag Minic, Gordana Markovic-Sovtic, Goran Z. Trajkovic, Goran Z. Trajkovic   +6 more
doaj   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Work of breathing in exercise and disease [PDF]

, 2010
This thesis is focussed on developing new methods and outcomes to assess respiratory function that require little or no volitional effort on behalf of the participants being tested.
Powell, Tom
core   +1 more source

Whole body composition analysis by the BodPod air-displacement plethysmography method in children with phenylketonuria shows a higher body fat percentage [PDF]

, 2010
BACKGROUND: Phenylketonuria (PKU) causes irreversible central nervous system damage unless a phenylalanine (PHE) restricted diet with amino acid supplementation is maintained.
Margriet M. W. B. Hendriks, Marjolein Bonthuis, Gepke Visser, Hendriks, Margriet M. W. B., Monique Albersen, van den Hurk, Dorine A. M., de Koning, Tom J., Nicole M. de Roos, Bonthuis, Marjolein, Dorine A. M. van den Hurk, de Sain-van der Velden, Monique G. M., Albersen, Monique, Ems Carbasius Weber, Monique G. M. de Sain-van der Velden, de Roos, Nicole M., Weber, Ems Carbasius, Tom J. de Koning, Visser, Gepke   +17 more
core   +1 more source

Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study

BMJ Open Respiratory Research, 2020
Introduction Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF).
Matthew Shaw, Thomas Simon FitzMaurice, Paul Stephen McNamara, Dilip Nazareth, Caroline McCann, Ram Bedi, Martin Walshaw   +6 more
doaj   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source