Results 71 to 80 of about 34,853 (259)

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Cardiopulmonary Exercise Testing in Dysfunctional Breathing: A Case Series of Five Young Women

Respirology Case Reports
Dysfunctional breathing (DB) is an underdiagnosed condition in young patients presenting with unexplained exertional breathlessness. Cardiopulmonary exercise testing (CPET) provides valuable diagnostic insights in these challenging cases.
Arup Haldar, Raja Dhar, Diptendu Dey, Amrita Bhattacharya, Beauty Biswas, Shyam Krishnan   +5 more
doaj   +1 more source

Feasibility and usability of three consecutive nights with self‐applied, home polysomnography

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary In‐laboratory polysomnography, the gold‐standard for diagnosing sleep disorders, is resource‐demanding and not conducive to multiple night evaluations. Ambulatory polysomnography, especially when self‐applied, could be a viable alternative. This study aimed to assess the feasibility and reliability of self‐applied polysomnography over three ...
Dimitri Ferretti, Anna S. Islind, Kristín A. Ólafsdóttir, Sigridur Sigurdardottir, Kamilla R. Jóhannsdóttir, Jan Hedner, Ludger Grote, Erna Sif Arnardottir   +7 more
wiley   +1 more source

Lower-Extremity Arterial Air Plethysmography Evaluation

, 2014
Plethysmography is a noninvasive technique based on detecting small volume changes in the limb secondary to the cardiac cycle. These changes provide a methodology for qualitative assessment of arterial waveforms and are obtained in conjunction with the ...
Michalene McPharlin
core   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Chronic intermittent hypoxia‐mediated cognitive dysfunction in ovariectomized rats

Experimental Physiology
Obstructive sleep apnoea (OSA) is a prevalent cardiorespiratory disorder associated with significant neurocognitive consequences. Despite the higher prevalence of OSA in men, there is a strong association between OSA and Alzheimer's disease (AD), which ...
Emily C. Cheung, Joan B. Escobar, Bridget R. Alber, Caitlin Ribeiro, Ishan Abdullah, Grant Kowalik, Jeannette Rodriguez, Grey Harral, Makeda Melkie, Aman Gill, John T. Ketzenberger, John Bethea, Vsevolod Y Polotsky, Vivek Jain, Kathryn Schunke, Matthew W. Kay, David Mendelowitz   +16 more
doaj   +1 more source

Perfusion index as a predictor of hypotension following propofol induction - A prospective observational study

Indian Journal of Anaesthesia, 2017
Background and Aims: Hypotension during propofol induction is a common problem. Perfusion index (PI), an indicator of systemic vascular resistance, is said to be predictive of hypotension following subarachnoid block.
Sripada G Mehandale, Preethi Rajasekhar
doaj   +1 more source

The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose [PDF]

, 2004
Background Considerable variation exists in the protocols used to induce hyperresponsiveness in murine models of allergic sensitisation. We examined the effect of varying the number of antigen exposures at challenge on the development of methacholine ...
Sly, P.D., Stumbles, P.A., Zosky, G.R., von Garnier, C., Holt, P.G., Turner, D.J.   +5 more
core  

Lower-Extremity Arterial Air Plethysmography Evaluation

, 2012
Plethysmography is a noninvasive technique based on detecting small volume changes in the limb secondary to the cardiac cycle. These changes provide a methodology for qualitative assessment of arterial waveforms and are obtained in conjunction with the ...
Michalene McPharlin
core   +1 more source

Slow Wave Activity During Nocturnal Sleep in Hypersomnolence Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT Slow waves during non‐rapid eye movement (NREM) sleep are associated with the restorative aspects of sleep. Previous research has suggested reduced normalized slow wave activity (SWA), particularly in the first cycle of NREM sleep, as a feature of hypersomnolence disorder (HD); however, the scarcity of existing research highlights the need for
Jesse D. Cook, Brady A. Riedner, Meredith E. Rumble, Michael R. Goldstein, Ana Maria Vascan, Kieulinh M. Tran, David T. Plante   +6 more
wiley   +1 more source