Results 81 to 90 of about 51,698 (318)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Total lung capacity by plethysmography and high-resolution computed tomography in COPD

International Journal of COPD, 2012
Jamie L Garfield, Nathaniel Marchetti, John P Gaughan, Robert M Steiner, Gerard J CrinerDepartment of Pulmonary and Critical Care Medicine and Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USAAim: To ...
Garfield JL, Marchetti N, Gaughan JP, Steiner RM, Criner GJ   +3 more
doaj  

A Novel Technique for the Measurement of Chest Wall Kinematics Using Low Cost Stretch Sensors

Sukkur IBA Journal of Emerging Technologies
Measurement of breathing patterns and thoracoabdominal movement (chest wall kinematics) is essential in studying patients with chronic obstructive pulmonary diseases (COPD), patients with neuromuscular diseases, critical patients in intensive care units
Atiqa Saleem, Zainab Ali, Rida Nisar, Muhammad Usman Raja   +3 more
doaj   +1 more source

Microneurografia e pletismografia de oclusão venosa na insuficiência cardíaca: correlação com prognóstico Microneurografía y pletismografía de oclusión venosa en la insuficiencia cardiaca: correlación con pronóstico Microneurography and venous occlusion plethysmography in heart failure: correlation with prognosis

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: Microneurografia e pletismografia de oclusão venosa podem ser considerados métodos de avaliação da atividade simpática. OBJETIVO: Avaliar a intensidade da atividade simpática através da microneurografia e da pletismografia de oclusão venosa ...
Robinson Tadeu Munhoz, Carlos Eduardo Negrão, Antonio Carlos Pereira Barretto, Marcelo Eidi Ochiai, Juliano Novaes Cardoso, Paulo Cesar Morgado, Carlos Henrique Del Carlo, José Antonio Franchini Ramires   +7 more
doaj   +1 more source

Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences [PDF]

, 2023
Renata C.N. Marchette, Erika R. Carlson, Emma V. Frye, Lyndsay Hastings, Janaina C. M. Vendruscolo, Gustavo Mejias-Torres, Stephen J. Lewis, Aidan J. Hampson, Nora D. Volkow, Leandro F. Vendruscolo, George F. Koob   +10 more
openalex   +1 more source

Lung volumes identify an at-risk group in persons with prolonged secondhand tobacco smoke exposure but without overt airflow obstruction. [PDF]

, 2018
IntroductionExposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to ...
Arjomandi, Mehrdad, Blanc, Paul D, Bos, Bruce, Elicker, Brett, Geerts, Jeroen, Gold, Warren M, Keene, Jason, Stiner, Rachel K, van Koeverden, Ian, Zeng, Siyang   +9 more
core   +2 more sources

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Nutritional Status, Physical and Psychomotor Development of Premature Infants: A Prospective Observational Comparative Study

Педиатрическая фармакология, 2018
Background. The development of premature infants is slower than that of term ones, often due to nutritional status disorders in preterm infants. Objective.
Tatiana V. Turti, Anna A. Gorbacheva, Olga L. Lukoyanova   +2 more
doaj   +1 more source

Non‐epileptic paroxysmal events in Rett syndrome: A systematic review of case‐based and observational evidence

Developmental Medicine &Child Neurology, EarlyView.
This systematic review identifies and categorizes the spectrum of non‐epileptic paroxysmal events in Rett syndrome. Respiratory disturbances, behavioural episodes, and motor events were the most commonly reported. Improving clinician awareness and diagnostic clarity is key to avoiding unnecessary treatment and enhancing quality of life for individuals ...
Natasha Bhatti, Daniel E. Lumsden
wiley   +1 more source

Acute Effects of Inspiratory Loads and Interfaces on Breathing Pattern and Activity of Respiratory Muscles in Healthy Subjects

Frontiers in Physiology, 2019
ObjectivesThe aim of this study was to evaluate the acute effects of different inspiratory loads and different interfaces on the breathing pattern and activity of the respiratory muscles.MethodsTwenty healthy adults were recruited and assigned to two ...
Jéssica Danielle Medeiros da Fonsêca, Jéssica Danielle Medeiros da Fonsêca, Vanessa Regiane Resqueti, Vanessa Regiane Resqueti, Kadja Benício, Kadja Benício, Guilherme Fregonezi, Guilherme Fregonezi, Andrea Aliverti   +8 more
doaj   +1 more source