Results 31 to 40 of about 68,618 (212)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Retrospective cohort study of survival length in malignant pleural effusion between 2015 and 2023

BMJ Open Respiratory Research
Background Malignant pleural effusion (MPE) is common, affecting approximately 15% of patients with cancer. Over recent years, there have been significant changes in both the diagnostic and therapeutic strategies for the condition, and recent ...
Najib Rahman, Rob Hallifax, Dinesh Addala, Anand Sundaralingam, Beenish Iqbal, Alguili Elsheikh, Craig Mounsey, Nikolaos Kanellakis, Wui Mei Chew, Imogen Mechie   +9 more
doaj   +1 more source

Giant Pleural Hydatid Cyst: A Case Report

Jurnal Respirasi, 2023
Introduction: Echinococcosis is a zoonotic disease caused by the larva stage of a Taeniidae parasite of Echinococcus. Echinococcus granulosus (E. granulosus) causes cystic echinococcus (CE) and is the most common species causing disease in humans.
Sudarto Sudarto, Selli Belinda, Alif Fathurrachman, Linda Andriani, Rouly Pasaribu, Ahmad Rasyid, Zen Ahmad, Tommy Setiawan   +7 more
doaj   +1 more source

Thoracoscopic techniques in the diagnosis and surgical treatment of pleural effusions—advantages and disadvantages of different thoracoscopic approaches [PDF]

Introduction: Pleural effusions are among the most commonly encountered conditions in the field of thoracic surgery. There are numerous diagnostic and treatment options, but the timing and precise choice of intervention remains critical.Aim: The aim of ...
Marinova, Katerina; Medical University of Varna
core   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Squamous cell carcinoma as a primary pleural tumor – case report

Journal of Education, Health and Sport, 2022
The differential diagnosis of primary pleural tumors is a very difficult challenge. The clinical symptoms are insufficient to make a clear and definitive diagnosis.
Katarzyna Szklener, Agnieszka Kopystecka, Patrycja Hatala, Martyna Gruba, Mateusz Glaza, Sławomir Mańdziuk   +5 more
doaj   +1 more source

Bacterial Infection Elicits Heat Shock Protein 72 Release from Pleural Mesothelial Cells [PDF]

, 2013
Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro
Porcel, JM, Bielsa, S, Brown, JS, della Vergiliana, JFV, Temple, SEL, Waterer, GW, Lee, YCG, Lansley, SM, Creaney, J   +8 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malignant pleural effusion: Updates in diagnosis, management and current challenges

Frontiers in Oncology, 2022
Malignant pleural effusion (MPE) is a common condition which often causes significant symptoms to patients and costs to healthcare systems. Over the past decade, the management of MPE has progressed enormously with large scale, randomised trials ...
Dinesh Narayan Addala, Dinesh Narayan Addala, Nikolaos I. Kanellakis, Nikolaos I. Kanellakis, Nikolaos I. Kanellakis, Eihab O. Bedawi, Eihab O. Bedawi, Tao Dong, Tao Dong, Najib M. Rahman, Najib M. Rahman, Najib M. Rahman, Najib M. Rahman   +12 more
doaj   +1 more source

Management of Pulmonary Hydatid Cyst With Pleural Complications: A Case Series [PDF]

, 2021
Introduction: The aim of this observational, retrospective study was to review and describe clinical presentations and management of patients with pulmonary hydatid cysts (PHC) and pleural complications. Methods: Complete case records from the previous 2
Anshuman Darbari, Mayank Mishra, Navin Kumar, Ajay Kumar, Sandeep Gautam, Raja Lahiri   +5 more
core   +1 more source