Results 131 to 140 of about 42,358 (170)

PLGA Microspheres Encapsulating siRNA

2014
The therapeutic use of small interfering RNA (siRNA) represents a new and powerful approach to suppress the expression of pathologically genes. However, biopharmaceutical drawbacks, such as short half-life, poor cellular uptake, and unspecific distribution into the body, hamper the development of siRNA-based therapeutics.
DE ROSA, GIUSEPPE, SALZANO, GIUSEPPINA
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A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel

Journal of Drug Targeting, 2010
The aim of this study was to investigate the suitability of poly-(d,l-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer as a matrix material for a sustained-release system for docetaxel (DTX). The copolymers were synthesized by ring-opening polymerization reaction and characterized by (1)H-NMR and gel permeation ...
Yuan, Gao, Fuzheng, Ren, Baoyue, Ding, Ningyun, Sun, Xiang, Liu, Xueying, Ding, Shen, Gao   +6 more
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Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Advanced Healthcare Materials, 2017
AbstractPoly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix.
Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento   +3 more
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Rheological properties of PLGA‐PEG‐PLGA copolymers for ophthalmic injection

Journal of Applied Polymer Science, 2011
AbstractPolymer rheological property is one of intrinsic properties for the design and preparation of intravitreal injection systems. Rheological behaviors of thermosensitive poly(lactic acid‐co‐glycolic acid)‐poly(ethylene glycol)‐poly(lactic acid‐co‐glycolic acid) (PLGA‐PEG‐PLGA) triblock copolymers were investigated in this article.
Bochu Wang, Yang Cao, Lichun Yang, Yazhou Wang   +3 more
openaire   +1 more source

Self-healing of pores in PLGAs

Journal of Controlled Release, 2015
Self-healing of pores in Poly(lactic-co-glycolic acid)s (PLGA) plays an important role in the encapsulation and controlled release of drugs from PLGA microparticles. Despite the importance of this phenomenon, neither the mechanics of the deformation nor the material properties that control it have been fully studied.
J, Huang, J M, Mazzara, S P, Schwendeman, M D, Thouless   +3 more
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Solubility of Ketoprofen in colloidal PLGA

International Journal of Pharmaceutics, 2010
The successful design and development of pharmaceutical drug-polymer composites requires detailed information about the phase behavior of the drug-polymer binary system. This study presents an extended investigation of the phase equilibrium established between the chiral anti-inflammatory drug Ketoprofen (KET) and the bio-compatible and biodegradable ...
Kluge J, Mazzotti M, Muhrer G
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PLGA Nanoparticles and Transdermal Delivery

Recent Patents on Nanotechnology, 2023

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Functionalization Conditions of PLGA‐PEG‐PLGA Copolymer with Itaconic Anhydride

Macromolecular Symposia, 2010
AbstractSummary: Biodegradable thermosensitive triblock copolymers based on poly(ethylene glycol) and poly(lactic‐co‐glycolic acid) (PLGA‐PEG‐PLGA) prepared via ring opening polymerization were modified by itaconic anhydride (ITA), which gives copolymer both reactive double bonds and functional carboxylic acid groups essential for the reaction with ...
Lenka Michlovská, Lucy Vojtová, Ludmila Mravcová, Soňa Hermanová, Jiří Kučerík, Josef Jančář   +5 more
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Synthesis and characterization of PLGA nanoparticles

Journal of Biomaterials Science, Polymer Edition, 2006
Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques ...
Carlos E, Astete, Cristina M, Sabliov
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The thermogelling PLGA–PEG–PLGA block copolymer as a sustained release matrix of doxorubicin

Biomaterials Science, 2013
This study is aimed at extending a thermo-induced physical hydrogel as a localized delivery system of the antitumor drug doxorubicin (DOX). An amphiphilic triblock copolymer consisting of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) was synthesized.
Lin, Yu, Tianyuan, Ci, Shuchun, Zhou, Wenjiao, Zeng, Jiandong, Ding   +4 more
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