Results 161 to 170 of about 44,745 (266)

Olmesartan-Loaded PLGA Nanoparticles Attenuate Methotrexate-Induced Kidney Injury: Association with the AT1R/ERK1/2 Signaling Axis. [PDF]

Pharmaceuticals (Basel)
Alawad OM, Tantawy N, Elsalhy S, Ahmed AA, Nofal S, Raafat EM.   +5 more
europepmc   +1 more source

Negative Chemotaxis of Urease‐Functionalized Polymeric Microcapsules

Small, EarlyView.
Urease‐functionalized PLGA microcapsules exhibit negative chemotaxis in urea gradients, migrating from high to low substrate concentrations. Increasing gradients enhance chemotaxis until a plateau, while increasing average substrate concentration in a fixed gradient reverses chemotactic behavior.
Amanda Hopkins, Daeyeon Lee, Daniel A. Hammer   +2 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

The improvement of diosmin dissolution by PLGA complexes for oral delivery: physicochemical characterization and anti-inflammatory evaluation. [PDF]

RSC Adv
Ton AK, Phan TT, Tran MT, Huynh TK, Nguyen HP, Nguyen TC, Hoang TK.   +6 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Intradiscal Delivery of Notoginsenoside R1-Loaded PLGA Nanoparticles Attenuates Intervertebral Disc Degeneration in Rats. [PDF]

J Cell Mol Med
Zheng B, Zhong H, Wang Z, Qin J, Xie Z, Tang R, Hu C, Zhang X, Li J, Li S.   +9 more
europepmc   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Lymph Node-Targeted PLGA-EgG1Y162 Nanovaccine for Synergistic Immunity Against <i>Echinococcus granulosus</i> Infection. [PDF]

Int J Nanomedicine
Aizezi M, Tuohetali A, Maimaiti M, Li X, Song Y, Chen X, Chen G, Abula S, Gao H, Yan R, Aimulajiang K.   +10 more
europepmc   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Targeted Nanoparticles for PROTAC-Mediated JAK1/JAK2 Degradation for Bladder Cancer Treatment. [PDF]

Int J Nanomedicine
Ding W, Zhang X, Wu H, Zhou C, Xu K, Tai Z, Xia G.   +6 more
europepmc   +1 more source