Results 171 to 180 of about 44,745 (266)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Morin-Loaded PLGA-Chitosan Nanoparticles Attenuate PTZ-Induced Seizure-Related Behavioral, Biochemical, and Transcriptional Changes in Male Rats. [PDF]

Pharmaceutics
Kakoo A, Kheder AH, Mohammedsaeed AA, Mohamad TS, Ali MA, Ghayour MB, Abdolmaleki A, Rahman DB, Abdulqadir SZ, Rasheed TK, Hashm MJ, Smail SW.   +11 more
europepmc   +1 more source

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

Biofabrication and Characterization of Fluorapatite-Coated Poly(lactic-co-glycolic acid) Microscaffolds: Physicochemical Properties and Human Dental Pulp Stem Cell Responses. [PDF]

J Funct Biomater
Raouf SH, Platania V, Lamprou A, Arntz Y, Lysova I, Bakr DK, Hamasaeed NH, Özcan M, Bugueno IM.   +8 more
europepmc   +1 more source

Membranes for Periodontal and Bone Regeneration: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This paper presents and highlights a summary of the past, present, and future of membranes for oral regeneration in clinical applications and fundamental studies. ABSTRACT Implant dentistry and periodontology have shown an increasing demand for regenerative procedures associated with biomaterials targeting successful clinical outcomes and predictable ...
Marcel F. Kunrath, Gabriel L. Magrin, Candida S. Zorzo, Ingrid Rigotto, Hanna Aludden, Christer Dahlin   +5 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Synergistically reinforced bioresorbable hydrogel for mechanical-biological decoupling and osteogenic-angiogenic coupling. [PDF]

Mater Today Bio
Hong Y, Lu H, Luo J, Li Y, Ye Y, Hua Y, Xu H, Xu T.   +7 more
europepmc   +1 more source

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

Transcending Nano-Encapsulation: Engineering Campesterol-Loaded Shellac-PLGA Nanosystem for Breast Cancer Therapy Supported by DFT and Molecular Docking. [PDF]

Int J Nanomedicine
Shah HS, Ghani S, Usman F, Chohan TA, Naeem N, Khan R, Ahmad H, Nasrullah U, Zargar S, Wani TA.   +9 more
europepmc   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source