Results 51 to 60 of about 7,959 (278)

Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex [PDF]

, 2012
Protein interactions within regulatory networks should adapt in a spatiotemporal-dependent dynamic environment, in order to process and respond to diverse and versatile cellular signals. However, the principles governing recognition pliability in protein
Nagulapalli, Malini, Matsoukas, John, Babu, M. Madan, Luchinat, Claudio, Parigi, Giacomo, Gerothanassis, Ioannis P., de Planque, Maurits R.R., Tzakos, Andreas G., Gsponer, Joerg, Yuan, Jing, Deraos, George, Bamm, Vladimir V., Harauz, George   +12 more
core   +3 more sources

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Controlling Change Within Complex Systems Through Pliability [PDF]

, 2012
As systems become larger, more complex, and operate for longer periods of time, some change within the system often becomes inevitable. Particularly in systems of systems, with diverse stakeholders, evolutionary development and managerial independence ...
Ross, Adam Michael, Mekdeci, Brian, Rhodes, Donna H., Hastings, Daniel E.   +3 more
core  

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

Advanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo, Shuo Qu, Shiming Gao, Xu Song   +3 more
wiley   +1 more source

Genetic influence on scar height and pliability after burn injury in individuals of European ancestry: A prospective cohort study [PDF]

, 2018
After similar extent of injury there is considerable variability in scarring between individuals, in part due to genetic factors. This study aimed to identify genetic variants associated with scar height and pliability after burn injury.
Martin, Lisa J, Marlow, Karen, Crowe, Margaret M, Wallace, Hilary J, Wallace, H., Falder, S., Ward, S., Wood, Fiona M, Fear, M., Cadby, Gemma, Melton, Phillip, Fear, Mark W, Wood, F., Crowe, M., Ward, Sarah V, Falder, Sian, Cadby, G., Marlow, K., Melton, Phillip E, Martin, L.   +19 more
core   +2 more sources

Variable Stiffness Flexure Structures Enabled by Phase‐Change Gallium and Adhesive Interfacial Locking for Soft Robotic Applications

Advanced Engineering Materials, EarlyView.
A flexure‐based variable stiffness structure is developed by integrating phase‐change modulation and adhesive interfacial locking of gallium. The design enables a wide stiffness variability, transitioning from soft, flexible behavior to rigid, load‐supporting performance.
Sungjin Kim, Sohee John Yoon, Yong‐Lae Park   +2 more
wiley   +1 more source

Tectonic Tenon transplants for four different corneal melts

Indian Journal of Ophthalmology. Case Reports, 2022
Tenon's tissue with good tensile strength, pliability, and availability is a valuable patch graft resource for small corneal perforations. We have extended its tectonic use to other corneal melts and leaks with anatomic success. Tenon's patch graft (TPG)
Radhika Natarajan, Nimisha Nagpal
doaj   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source