Results 1 to 10 of about 87,114 (318)

Tumor ploidy determination in low-pass whole genome sequencing and allelic copy number visualization using the Constellation Plot [PDF]

Genome Biology
Ploidy determination across the genome has been challenging for low-pass-WGS tumor-only samples. We present BACDAC, a method that calculates tumor ploidy down to 1.2X effective tumor coverage.
Sarah H. Johnson, James B. Smadbeck, Roman M. Zenka, Michael T. Barrett, Athanasios Gaitatzes, Arnav Solanki, Angela B. Florio, Mitesh J. Borad, John C. Cheville, George Vasmatzis   +9 more
doaj   +2 more sources

Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans.

PLoS Genetics, 2021
Genome copy number variation occurs during each mitotic and meiotic cycle and it is crucial for organisms to maintain their natural ploidy. Defects in ploidy transitions can lead to chromosome instability, which is a hallmark of cancer.
Ci Fu, Aaliyah Davy, Simeon Holmes, Sheng Sun, Vikas Yadav, Asiya Gusa, Marco A Coelho, Joseph Heitman   +7 more
doaj   +1 more source

Increased Virulence and Large-Scale Reduction in Genome Size of Tetraploid Candida albicans Evolved in Nematode Hosts

Frontiers in Fungal Biology, 2022
Candida albicans is an opportunistic fungal pathogen of humans, yet the within-host dynamics of C. albicans infection are not clear. While C. albicans is commonly diploid, it exhibits a range of ploidies, including tetraploidy.
Amanda C. Smith, Amanda C. Smith, Hassan Rizvi, Meleah A. Hickman, Meleah A. Hickman, Levi T. Morran   +5 more
doaj   +1 more source

Extreme Polyploidy of Carsonella, an Organelle-Like Bacterium with a Drastically Reduced Genome

Microbiology Spectrum, 2022
Polyploidy is the state of having multiple copies of the genome within a nucleus or a cell, which has repeatedly evolved across the domains of life. Whereas most bacteria are monoploid, some bacterial species and endosymbiotic organelles that are derived
Atsushi Nakabachi, Nancy A. Moran
doaj   +1 more source

Discovery and Characterization of Novel Fertile Triploids and a New Chromosome Number in Caladium (Caladium × hortulanum)

HortScience, 2022
Cultivated caladium (Caladium × hortulanum; 2n = 2x = 30) is an important ornamental aroid for the environmental horticulture industry. A better understanding of its genetic diversity is needed for continued improvement of caladium.
S. Brooks Parrish, Zhanao Deng
doaj   +1 more source

Coping with environmental constraints: Geographically divergent adaptive evolution and germination plasticity in the transcontinental Populus tremuloides

Plants, People, Planet, 2022
Societal Impact Statement Syntheses clearly show that global warming is affecting ecosystems and biodiversity around the world. New methods and measures are needed to predict the climate resilience of plant species critical to ecosystem stability, to ...
Roos Goessen, Nathalie Isabel, Christian Wehenkel, Nathalie Pavy, Lisa Tischenko, Lyne Touchette, Isabelle Giguère, Marie‐Claude Gros‐Louis, Jérôme Laroche, Brian Boyle, Raju Soolanayakanahally, Karen Mock, Javier Hernández‐Velasco, Sergio Leonel Simental‐Rodriguez, Jean Bousquet, Ilga M. Porth   +15 more
doaj   +1 more source

Are tri‐pronuclear embryos that show two normal‐sized pronuclei and additional smaller pronuclei useful for embryo transfer?

Reproductive Medicine and Biology, 2022
Purpose This study aimed to analyze whether tripronuclear (3PN) zygotes, with two normal‐sized PNs and an additional smaller PN (2.1PN), can be used for embryo transfer.
Hiromi Takahashi, Rei Hirata, Junko Otsuki, Toshihiro Habara, Nobuyoshi Hayashi   +4 more
doaj   +1 more source

Chromosome Painting Provides Insights Into the Genome Structure and Evolution of Sugarcane

Frontiers in Plant Science, 2021
The genus Saccharum is composed of species with high polyploidy and highly varied chromosome numbers, laying a challenge for uncovering its genomic structure and evolution.
Zhuang Meng, Zhuang Meng, Qinnan Wang, Haris Khurshid, Ghulam Raza, Jinlei Han, Baohua Wang, Kai Wang, Kai Wang   +8 more
doaj   +1 more source

Evolution of Reproductive Division of Labor – Lessons Learned From the Social Amoeba Dictyostelium discoideum During Its Multicellular Development

Frontiers in Cell and Developmental Biology, 2021
The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy, Shashi P. Singh   +1 more
doaj   +1 more source

Quantification of ploidy in proteobacteria revealed the existence of monoploid, (mero-)oligoploid and polyploid species [PDF]

, 2011
Bacteria are generally assumed to be monoploid (haploid). This assumption is mainly based on generalization of the results obtained with the most intensely studied model bacterium, Escherichia coli (a gamma-proteobacterium), which is monoploid during ...
Lange, Christian, Pecoraro, Vito, Soppa, Jörg (Prof. Dr.), Zerulla, Karolin   +3 more
core   +3 more sources