Results 201 to 210 of about 64,688 (330)

Biopsy‐derived organoids in personalised early breast cancer care: Challenges of tumour purity and normal cell overgrowth cap their practical utility

open access: yesInternational Journal of Cancer, Volume 156, Issue 11, Page 2200-2209, 1 June 2025.
What's new? Breast cancer patients often face relapse, sometimes years after initially successful therapy. It would therefore be highly desirable to develop a platform enabling routine assaying of individual efficacy of personalised therapies. Organoids have been proposed as a tool to serve this purpose, but the feasibility of their establishment from ...
Paul Schwerd‐Kleine   +18 more
wiley   +1 more source

Bamboozle: A Bioinformatic Tool for Identification and Quantification of Intraspecific Barcodes

open access: yesMolecular Ecology Resources, Volume 25, Issue 4, May 2025.
ABSTRACT Evolutionary changes in populations of microbes, such as microalgae, cannot be traced using conventional metabarcoding loci as they lack intraspecific resolution. Consequently, selection and competition processes among strains of the same species cannot be resolved without elaborate isolation, culturing, and genotyping efforts.
Matthew I. M. Pinder   +5 more
wiley   +1 more source

Dual and spatially resolved drought responses in the Arabidopsis leaf mesophyll revealed by single‐cell transcriptomics

open access: yesNew Phytologist, Volume 246, Issue 3, Page 840-858, May 2025.
Summary Drought stress imposes severe challenges on agriculture by impacting crop performance. Understanding drought responses in plants at a cellular level is a crucial first step toward engineering improved drought resilience. However, the molecular responses to drought are complex as they depend on multiple factors, including the severity of drought,
Rubén Tenorio Berrío   +6 more
wiley   +1 more source

Short‐Term High Light Stress Analysis Through Differential Methylation Identifies Root Architecture and Cell Size Responses

open access: yesPlant, Cell &Environment, Volume 48, Issue 5, Page 3269-3280, May 2025.
ABSTRACT DNA methylation repatterning is an epigenomic component of plant stress response, but the extent that methylome data can elucidate changes in plant growth following stress onset is not known. We applied high‐resolution DNA methylation analysis to decode plant responses to short‐ and long‐term high light stress and, integrating with gene ...
Akshay U. Nair   +5 more
wiley   +1 more source

Pronuclear Location Before the First Cell Division Determines Ploidy of Polyspermic Pig Embryos1 [PDF]

open access: bronze, 1999
Yong‐Mahn Han   +7 more
openalex   +1 more source

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