Results 41 to 50 of about 90,784 (353)

Prognostic significance of DNA cytometry in cutaneous malignant lymphomas. [PDF]

, 1991
The current classification of cutaneous malignant lymphomas (ML) into low-grade and high-grade lymphomas was found to be of limited reproducibility and permitted only a rough prediction about outcome.
Abmayr, Wolfgang, Braun-Falco, Otto, Burg, Günter, Dummer, Reinhard, Eckert, Fritjof, Kaudewitz, Peter, Stolz, Wilhelm, Vogt, Thomas   +7 more
core   +1 more source

p53: Guardian of ploidy

Molecular Oncology, 2011
AbstractAneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression. True to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either ...
Aylon, Yael, Oren, Moshe
openaire   +4 more sources

Cellular cannibalism: An insight

CHRISMED Journal of Health and Research, 2015
The phenomenon of cell cannibalism refers to the engulfment of cells within other cells. It is an unusual phenomenon associated with poor prognosis of high-grade cancers.
Deepti Sharma, George Koshy, Sonal Grover, Shinu Koshy   +3 more
doaj   +1 more source

WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing. [PDF]

, 2013
MotivationCopy number variations (CNVs) are a major source of genomic variability and are especially significant in cancer. Until recently microarray technologies have been used to characterize CNVs in genomes.
Ali, Johar, Arshadi, Niloofar, Beck, Tim, Holt, Carson, Jang, Gun Ho, Losic, Bojan, McPherson, John, Muthuswamy, Lakshmi B, Pai, Deepa, Syam, Sujata, Trinh, Quang, Zhao, Zhen   +11 more
core   +3 more sources

Tumor ploidy determination in low-pass whole genome sequencing and allelic copy number visualization using the Constellation Plot

Genome Biology
Ploidy determination across the genome has been challenging for low-pass-WGS tumor-only samples. We present BACDAC, a method that calculates tumor ploidy down to 1.2X effective tumor coverage.
Sarah H. Johnson, James B. Smadbeck, Roman M. Zenka, Michael T. Barrett, Athanasios Gaitatzes, Arnav Solanki, Angela B. Florio, Mitesh J. Borad, John C. Cheville, George Vasmatzis   +9 more
doaj   +1 more source

Is Natural Population of Candida tropicalis Sexual, Parasexual, and/or Asexual?

Frontiers in Cellular and Infection Microbiology, 2021
Candida tropicalis is one of the most common opportunistic yeast pathogens of humans, especially prevalent in tropical and subtropical regions. This yeast has broad ecological distributions, can be found in both terrestrial and aquatic ecosystems ...
Jianping Xu, Jianping Xu
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Virulence phenotypes result from interactions between pathogen ploidy and genetic background

Ecology and Evolution, 2020
Studying fungal virulence is often challenging and frequently depends on many contexts, including host immune status and pathogen genetic background. However, the role of ploidy has often been overlooked when studying virulence in eukaryotic pathogens ...
Dorian J. Feistel, Rema Elmostafa, Meleah A. Hickman   +2 more
doaj   +1 more source

Energetic budget of diploid and triploid eastern oysters during a summer die-off

Frontiers in Marine Science, 2023
Triploid oysters are widely used in off-bottom aquaculture of eastern oysters, Crassostrea virginica. However, farmers of the Gulf of Mexico (GoM) and Atlantic coast estuaries have observed unresolved, late-spring die-offs of triploid oysters ...
Sarah Bodenstein, Sandra M. Casas, Terrence R. Tiersch, Jerome F. La Peyre   +3 more
doaj   +1 more source

Adaptation to high ethanol reveals complex evolutionary pathways [PDF]

, 2015
Tolerance to high levels of ethanol is an ecologically and industrially relevant phenotype of microbes, but the molecular mechanisms underlying this complex trait remain largely unknown.
Arslan, Ahmed, Das, Anupam, De Maeyer, Dries, DeLuna, Alexander, Espinosa-Cantú, Adriana, Jelier, Rob, Kominek, Jacek, Marchal, Kathleen, Meert, Wim, van der Zande, Elisa, Van Noort, Vera, Van Pee, Michiel, Verstrepen, Kevin J, Voordeckers, Karin, Yang, Yudi, Zhu, Bp   +15 more
core   +4 more sources