Results 111 to 120 of about 4,760,121 (354)

Application of Volcano Plots in Analyses of mRNA Differential Expressions with Microarrays

open access: yes, 2013
Volcano plot displays unstandardized signal (e.g. log-fold-change) against noise-adjusted/standardized signal (e.g. t-statistic or -log10(p-value) from the t test).
Alvord W. G.   +17 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

L'ANALYSE COMPTABLE DU RISQUE : LIMITES ET ENJEUX [PDF]

open access: yes
Cet article traite de l'information fournie sur les risques par les états financiers. Le risque se caractérise par deux dimensions : la probabilité d'occurrence et l'estimation des dommages. La comptabilité est incapable de traduire toutes ces dimensions,
Olivier Vidal, Plot Emmanuelle
core  

The effects of a chemosterilant (Mestranol) on population and behavior in the Richardson's ground squirrel (Spermophilus richardsonii) in Alberta [PDF]

open access: yes, 1974
A chemosterilant, mestranol, was administered to three populations of Richardson's ground squirrel in southeastern Alberta. Mestranol was given to all squirrels in one plot, to only 50 percent in another plot, while a third plot remained as control.
Goulet, Louise A., Sadleir, R. M. F. S.
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Review article: The mountain motif in the plot of Matthew

open access: yesHTS Teologiese Studies/Theological Studies, 2010
This article reviewed T.L. Donaldson’s book, Jesus on the mountain: A study in Matthean theology, published in 1985 by JSOT Press, Sheffield, and focused on the mountain motif in the structure and plot of the Gospel of Matthew, in addition to the work of
Gert J. Volschenk
doaj   +1 more source

Facilitating open plot structures in story driven video games using situation generation [PDF]

open access: yes, 2012
Story driven video games are rising in popularity, along with the players desire to make meaningful choice within the plot and therefore become more involved and immersed within the experience.
Brown, Gordon, King, David J.
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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