Results 131 to 140 of about 298,479 (352)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Hydrothermal vents supporting persistent plumes and microbial chemoautotrophy at Gakkel Ridge (Arctic Ocean)

Frontiers in Microbiology
Hydrothermal vents emit hot fluids enriched in energy sources for microbial life. Here, we compare the ecological and biogeochemical effects of hydrothermal venting of two recently discovered volcanic seamounts, Polaris and Aurora of the Gakkel Ridge, in
Gunter Wegener, Gunter Wegener, Gunter Wegener, Massimiliano Molari, Massimiliano Molari, Autun Purser, Alexander Diehl, Alexander Diehl, Elmar Albers, Elmar Albers, Elmar Albers, Maren Walter, Maren Walter, Christian Mertens, Christopher R. German, Antje Boetius, Antje Boetius, Antje Boetius   +17 more
doaj   +1 more source

A preliminary characterization of applied-field MPD thruster plumes [PDF]

Electric probes, quantitative imaging, and emission spectroscopy were used to study the plume characteristics of applied field magnetohydrodynamic thrusters.
Biaglow, James, Myers, Roger M., Reese, Shawn, Vernyi, Mark, Wehrle, David   +4 more
core   +1 more source

Formation and evolution of a metasomatized lithospheric root at the motionless Antarctic plate: the case of East Island, Crozet Archipelago (Indian Ocean) [PDF]

, 2016
Sitting atop the nearly stagnant Antarctic plate (ca. 6.46 mm/yr), the Crozet archipelago midway between Madagascar and Antarctica constitutes a region of unusually shallow (1543-1756 m below sea level) and thickened oceanic crust (10-16.5 km), high ...
Bellieni, Giuliano, Levresse, Gilles, Marzoli, Andrea, Meyzen, CHRISTINE MARIE   +3 more
core  

Overnight atmospheric transport and chemical processing of photochemically aged Houston urban and petrochemical industrial plume [PDF]

, 2010
R. A. Zaveri, P. B. Voss, Carl M. Berkowitz, Edward C. Fortner, Jun Zheng, Renyi Zhang, Ralph J. Valente, Roger L. Tanner, Daniel Holcomb, Thomas Hartley, Leslie Baran   +10 more
openalex   +1 more source

Comparison of non-local metrics towards the assimilation of pollutant plumes without thedouble penalty

, 2022
Pierre Vanderbecken, Alban Farchi, Marc Bocquet, Joffrey Dumont Le Brazidec, Yelva Roustan, Grégoire Broquet, Élise Potier   +6 more
openalex   +1 more source

Plume‐Induced Delamination Initiated at Rift Zones on Venus [PDF]

, 2023
Andrea C. Adams, D. R. Stegman, Hiva Mohammadzadeh, S. E. Smrekar, Paul Tackley   +4 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Simulations and Analyses of the Influence of a Vacuum Back-Pressure Environment on Laser Ablation Thrusters

Aerospace
The study of thruster plume flow fields can yield a series of thruster performance parameters such as thrust effect, spacecraft plume contamination, etc., which is of great significance for thruster development.
Ming Wen, Baosheng Du, Haichao Cui, Jianhui Han   +3 more
doaj   +1 more source

Ash plume properties retrieved from infrared images: a forward and inverse modeling approach

, 2014
We present a coupled fluid-dynamic and electromagnetic model for volcanic ash plumes. In a forward approach, the model is able to simulate the plume dynamics from prescribed input flow conditions and generate the corresponding synthetic thermal infrared (
Cerminara, Matteo, Harris, Andrew J. L., Ongaro, Tomaso Esposti, Valade, Sébastien   +3 more
core   +3 more sources