Results 111 to 120 of about 76,997 (309)

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Velocities in the plume of the 2010 Eyjafjallajökull eruption [PDF]

, 2013
The eruption of the Icelandic volcano Eyjafjallajökull in the spring of 2010 lasted for 39 days with an explosive phase (14–18 April), an effusive phase (18 April–4 May) and a phase with renewed explosive activity (5–17 May).
Bjornsson, Halldor, Arason, Pordur, Magnusson, Sindri, Björnsson, H., Petersen, Guðrún Nína, Magnusson, Sverker,, Petersen, G. N., Arason, P.   +7 more
core   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Numerical and Experimental Investigations of a Generic Rocket Launcher Configuration with Cold Plume in Hypersonic Flow

, 2013
A generic rocket launcher geometry is studied experimentally and numerically at hypersonic flow conditions including a cold plume. The experiments are conducted in a hypersonic Ludwieg tube while numerical calculations are performed with a finite-volume
Oßwald, Kai, Radespiel, Rolf, Hannemann, Volker, Stephan, Sören, Hannemann, Klaus   +4 more
core  

Remote sensing of the river Rhine plume

, 2004
The data content of remote sensing (RS) images of sea surface temperature (SST) and normalized water-leaving radiance (nLw), for the year 1998, with respect to the River Rhine plume, is investigated.
Arentz, L. (Loana), Arentz, L. (author)
core   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Engineering model for rocket exhaust plumes verified by CFD results

, 2013
An engineering model (EM) is under development that describes the propagation of a rocket exhaust plume after the nozzle exit. The aim of this EM is to allow a fast analysis of the structure of the plume and the exhaust species within the plume.
Minutolo, Francesco, Grenard, Philippe, Bauer, Carola, Koch, Aaron   +3 more
core  

Crustal flow beneath Iceland

Theoretical and experimental studies indicate that when oceanic crust is hotter than about 800°C, variations in crustal thickness drive lower crustal flow.
Maclennan, J., Jones, S. M.
core   +1 more source

PLUME & research software

, 2013
The PLUME open platform (https://www.projet-plume.org) has as first goal to share competences and to value the knowledge of software experts within the French higher education and research communities.
Gomez-Diaz, Teresa (4967926), Baudin, Véronique, Baudin, Véronique (4967923), Gomez-Diaz, Teresa   +3 more
core   +1 more source