Results 101 to 110 of about 267,896 (306)

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Properties and Dispersal of a Hydrothermal Plume in a Weakly Stratified Under‐Ice Environment

Geochemistry, Geophysics, Geosystems
The Aurora vent field (82°53.83′N, 6°15.32′W) is located in the weakly stratified Arctic Ocean under perennial ice cover at the western edge of the ultraslow‐spreading Gakkel Ridge, the slowest spreading mid‐ocean ridge on Earth.
Maren Walter, Andreas Türke, Alexander Diehl, Christopher R. German, Christian Mertens, Jonathan Mette, Patrick Monien, Simon Prause, Jürgen Sültenfuß, Wolfgang Bach, Vera Schlindwein, Antje Boetius   +11 more
doaj   +1 more source

Some features of the structure of the mantle of the Eastern Mediterranean and their geodynamic interpretation

Геофизический журнал, 2016
We consider specific velocity anomalies and the corresponding mantle structures of the East Mediterranean-Black Sea-Caspian region. The anomalies are located on latitudinal and longitudinal seismic tomography sections obtained by constructing 3D P ...
O. B. Gintov, T. A. Tsvetkova, I. V. Bugaenko, A. V. Murovskaya   +3 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

From new geological paradigm to the problems of regional geological-geophysical survey

Геофизический журнал, 2018
Analysis of the latest scientific achievements in different areas of geological and geophysical research showed that investigation of deep Earth degassing from its core up to the surface and atmosphere acquires status of the mainstream in the Earth ...
A. Lukin, V. Shestopalov
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Microstructure‐Resolved Modeling to Predicting and Regulating Lithium Plating‐Stripping Dynamics on Graphite Electrodes

Advanced Science, EarlyView.
ABSTRACT The lithium plating reaction in graphite electrodes acts as a root cause for the accelerated degradation and the internal short circuits in lithium‐ion batteries. Here, an electrochemical model based on multi‐scale microstructural images was established to identify lithium plating‐stripping processes, thereby supporting the predictive outcomes
Heng Huang, Yang Li, Xinyu Liu, Zhifu Zhou, Wei‐Tao Wu, Lei Wei, Chengzhi Hu, Linsong Gao, Yubai Li, Yongchen Song   +9 more
wiley   +1 more source

Is Enceladus' plume tidally controlled?

Geophysical Research Letters, 2008
Explanations for the plume of gas, water vapor and ice particles jetting from rifts in Enceladus' south polar region include boiling of liquid water and dissociation of clathrate hydrates.
I. Halevy, S. T. Stewart
doaj   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Velocity structure of the Earth’s crust and upper mantle in the Pechenga ore region and adjacent areas in the northwestern part of the Lapland-Kola orogen by the receiver function technique

Записки Горного института
The article presents a study of the Earth’s crust and upper mantle in the Pechenga ore region, as well as areas adjacent to it in the northwestern part of the Kola region.
Andrei G. Goev
doaj