Results 91 to 100 of about 100,677 (249)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The effect of sudden source buoyancy flux increases on turbulent plumes [PDF]

, 2009
Building upon the recent experimentally verified modelling of turbulent plumes which are subject to decreases in their source strength (Scase et al., J. Fluid Mech., vol. 563, 2006b, p.
SCASE, M. M., Caulfield, C., Scase, M., CAULFIELD, C. P., Aspden, Andrew, ASPDEN, A. J.   +5 more
core   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Properties and Dispersal of a Hydrothermal Plume in a Weakly Stratified Under‐Ice Environment

Geochemistry, Geophysics, Geosystems
The Aurora vent field (82°53.83′N, 6°15.32′W) is located in the weakly stratified Arctic Ocean under perennial ice cover at the western edge of the ultraslow‐spreading Gakkel Ridge, the slowest spreading mid‐ocean ridge on Earth.
Maren Walter, Andreas Türke, Alexander Diehl, Christopher R. German, Christian Mertens, Jonathan Mette, Patrick Monien, Simon Prause, Jürgen Sültenfuß, Wolfgang Bach, Vera Schlindwein, Antje Boetius   +11 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Numerical and Experimental Investigations of a Generic Rocket Launcher Configuration with Cold Plume in Hypersonic Flow [PDF]

, 2013
A generic rocket launcher geometry is studied experimentally and numerically at hypersonic flow conditions including a cold plume. The experiments are conducted in a hypersonic Ludwieg tube while numerical calculations are performed with a finite-volume
Oßwald, Kai, Radespiel, Rolf, Hannemann, Volker, Stephan, Sören, Hannemann, Klaus   +4 more
core  

Some features of the structure of the mantle of the Eastern Mediterranean and their geodynamic interpretation

Геофизический журнал, 2016
We consider specific velocity anomalies and the corresponding mantle structures of the East Mediterranean-Black Sea-Caspian region. The anomalies are located on latitudinal and longitudinal seismic tomography sections obtained by constructing 3D P ...
O. B. Gintov, T. A. Tsvetkova, I. V. Bugaenko, A. V. Murovskaya   +3 more
doaj   +1 more source

Stacking Pressure‐Driven Interfacial Dynamics in Anode‐Free Solid‐State Lithium Batteries

Advanced Science, EarlyView.
Using a three‐electrode setup, it is found that stacking pressure improves both anode and cathode interfaces but more effectively stabilizes the anode. Under low pressure, a sudden anode resistance rise indicates contact loss. Higher pressure delays this via Li creep and plastic deformation, maintaining interfacial contact.
Jianneng Liang, Matthias Bohnen, Ralf Müller, Robert Leiter, Simon Fleischmann, Shuya Gong, Mervyn Rohit Soans, Stefano Passerini, Alberto Varzi   +8 more
wiley   +1 more source

Velocity structure of the Earth’s crust and upper mantle in the Pechenga ore region and adjacent areas in the northwestern part of the Lapland-Kola orogen by the receiver function technique

Записки Горного института
The article presents a study of the Earth’s crust and upper mantle in the Pechenga ore region, as well as areas adjacent to it in the northwestern part of the Kola region.
Andrei G. Goev
doaj