Results 41 to 50 of about 100,389 (292)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Secondary Intrusion Formation of Multiphase Plumes
Frontiers in Marine Science, 2021 This work presents a new laboratory study for understanding secondary intrusions in multiphase plumes in quiescent, stratified environments. The study is driven by field observations of secondary intrusions during the Deepwater Horizon (DWH) oil spill ...
Dayang Wang, E. Eric Adams
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
ACADIA proceedingsPLUME This work continues a series of studies presented in The Great Flood, Two Worlds, and Basalt Continent, where planetary-scale geological structures and catastrophic transformations of the Earth’s surface were examined. While the previous works analysed the geomorphological and archaeological evidence of large-scale planetary events, the ...
Kory Bieg, Clay Odom
+6 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Fushe yanjiu yu fushe gongyi xuebaoDuring the normal operation of cooling towers in nuclear power plants, water vapor with a certain temperature is discharged through the outlet of the cooling tower, which mixes with the surrounding air. A portion of this vapor condenses and forms visible
ZHAO Dan +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Геодинамика и тектонофизика, 2019 We have studied variations in the structure and composition of minerals from the pipes of the Yakutian kimberlite province (YKP) in different mantle terranes of the Siberian craton.
I. V. Ashchepkov +7 more
doaj +1 more source