Results 61 to 70 of about 1,868,241 (285)

Development and optimization of a wildfire plume rise model based on remote sensing data inputs – Part 2

, 2015
. Biomass burning is one of a relatively few natural processes that can inject globally significant quantities of gases and aerosols into the atmosphere at altitudes well above the planetary boundary layer, in some cases at heights in excess of 10 km ...
R. Paugam, M. Wooster, J. Atherton, S. Freitas, M. Schultz, J. Kaiser   +5 more
semanticscholar   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Simple models for the simulation of submarine melt for a Greenland glacial system model [PDF]

The Cryosphere, 2018
Two hundred marine-terminating Greenland outlet glaciers deliver more than half of the annually accumulated ice into the ocean and have played an important role in the Greenland ice sheet mass loss observed since the mid-1990s.
J. Beckmann, M. Perrette, A. Ganopolski
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

GEODYNAMIC PROCESSES DURING ASCENT OF A PLUME WITH INTERMEDIATE THERMAL POWER THROUGH THE CONTINENTAL LITHOSPHERE AND DURING ITS ERUPTION ON THE SURFACE

Геодинамика и тектонофизика, 2020
The study is focused on thermochemical mantle plumes with intermediate thermal power (1.15 < Ka < 1.9). Previously we have shown that these plumes are diamondiferous.
A. G. Kirdyashkin, A. A. Kirdyashkin, V. E. Distanov, I. N. Gladkov   +3 more
doaj   +1 more source

Evidence for compositionally distinct upper mantle plumelets since the early history of the Tristan-Gough hotspot

Nature Communications, 2023
Recent studies indicate that mantle plumes, which transfer material and heat from the earth’s interior to its surface, represent multifaceted upwellings.
Stephan Homrighausen, Kaj Hoernle, Folkmar Hauff, Patrick A. Hoyer, Karsten M. Haase, Wolfram H. Geissler, Jörg Geldmacher   +6 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Wildfire plumes in the Western US are reaching greater heights and injecting more aerosols aloft as wildfire activity intensifies

Scientific Reports, 2022
By producing a first-of-its-kind, decadal-scale wildfire plume rise climatology in the Western U.S. and Canada, we identify trends toward enhanced plume top heights, aerosol loading aloft, and near-surface smoke injection throughout the American West ...
Taylor Y. Wilmot, Derek V. Mallia, A. Gannet Hallar, John C. Lin   +3 more
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source