Results 91 to 100 of about 69,541 (306)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Voting Equilibria in Multi-candidate Elections [PDF]
We consider a general plurality voting game with multiple candidates, where voter preferences over candidates are exogenously given. In particular, we allow for arbitrary voter indierences, as may arise in voting subgames of citizen-candidate or ...
Yoji Sekiya, John Duggan
core
Plurality or convergence in sustainability reporting standards?
Amfiteatru Economic, 2013 Over the last years an increasing number of companies issued Corporate Social Responsibility (CSR) or Sustainability Reports to complement their traditional financial reporting.
Nadia Albu +3 more
doaj
Plurality of Governance – Plurality of Systems
Journal of the Royal College of Physicians of Edinburgh, 2021 Nick, Woodier +4 more
openaire +2 more sources
Oxford Journal of Legal StudiesAbstract In Property Rights: A Re-Examination, James Penner returns to and develops a project that he has been engaged in for nearly three decades: to replace the influential ‘bundle of rights’ picture of property, which he regards as irredeemably flawed, with an alternative account—one that regards property as a unified entitlement.
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Plurality and Classifiers across languages in China
, 2012 International audienceIn human languages, plurality can be viewed as one way of expressing quantification, which can be expressed by height, length, weight, number, etc. Chinese is a language that does not require plural marking in noun phrases.
Xu, Dan
core
Literature in discussion I [PDF]
Slovenska Literatura, 1999 The work Literature in Discussion (Literatúra v diskusii) came into being in the period of Mečiar's to talization of civil society in Slovakia. It tries to offer synthetical information and a critical evaluation of the positives and negatives which 1990s
Stanislava Repar Chrobáková
doaj
'Parecen que lo olvidan': Plurals did it again
Borealis: An International Journal of Hispanic Linguistics, 2018 The distribution of DDPP in raising constructions –depending on the embedded clause’s formal properties– has been essential for Case Theory and movement. Likewise, the behavior of DDPP, according to agreement facts, has given rise to relevant discussions
María Mare, Enrique Pato
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source