Results 131 to 140 of about 24,248 (267)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Comparing Methods for Attributing Hospital Quality Metrics to Individual Physicians: Impact on Performance Assessment and Outlier Identification. [PDF]

J Gen Intern Med
Carmichael HL, Woller SC, Brown SM, Asch SM, Srivastava R, Pirozzi M, Peltan ID.   +6 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Infertility treatment and the growth of children from birth to 12 years of age: A national cohort study. [PDF]

PLoS One
Chang YS, Yu T, Wong TJ, Li CY.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

How Often Do Large Language Models Agree with Each Other-And with the Truth? A Consensus- and Complexity-Stratified Analysis of Data Extraction for Neuroimaging AI. [PDF]

J Clin Med
Sanlier N, Sulaimanov U, Moniri A, Demir B, Ismayilova G, Sanlier MY, Erginoglu U, Bayramoglu AR, Al-Jebur MS, Ammanuel SG, Otles E, Keles A, Erginoglu U, Baskaya MK.   +13 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Comment on "The imitation game: large language models versus multidisciplinary tumor boards: benchmarking AI against 21 sarcoma centers from the RING trial". [PDF]

J Cancer Res Clin Oncol
Shanmuga Priya M, Aruthra, Srinivasa Galu K, Anish Kumar A.   +3 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Beyond the autonomous individual: hydrosocial relations and the constitution of the relational hydrosocial self in an Andean conflict. [PDF]

Front Sociol
Oré Gálvez SF, Molina Linares AF, Phocco Minaya JL, Quispe Quispe A, Carhuallanqui Ibarra SD, Terres León JC, Ñaupari Molina R, Barnes CHW, Valladares LLS.   +8 more
europepmc   +1 more source