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The effect of the non ionic surfactant Pluronic F68 on mammalian cells in culture
, 2003 openaire +1 more source
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Rheology and morphology of Pluronic F68 in water
Physics of Fluids, 2021We investigated the morphological transitions of aqueous solutions of Pluronic F68 induced by temperature and polymer concentration by means of rheological and x-ray measurements. We adopted a rheological method to evaluate the characteristic equilibrium temperatures associated with the transition from unimers to spherical micelles and from disordered ...
Costanzo S. +8 more
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Effects of pluronic F68 micellization on the viability of neuronal cells in culture [PDF]
Journal of Applied Polymer Science, 2013 ABSTRACTTriblock copolymers with surface‐active properties, referred to as Pluronic, have shown potential medical applications such as drug delivery to selective targets in the human body. In particular, the transport of anti‐inflammatory substances to the brain is required for illness treatment, thus the study of delivery agents that cross the blood ...
Nicolás Arancibia-Miranda, German Mino
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Chemical modification, electrospinning and biological activities of pluronic F68
Polymer Bulletin, 2022El-Refaie Kenawy, Mohamed M Azaam
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Archives of Pharmacal Research, 2011
The aim of this study was to investigate the effects of Pluronic F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin. Intestinal permeability of rifampicin with or without excipients was evaluated by an in situ single-pass perfusion method.
Xin-An Wu, Yuhui Wei
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The aim of this study was to investigate the effects of Pluronic F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin. Intestinal permeability of rifampicin with or without excipients was evaluated by an in situ single-pass perfusion method.
Xin-An Wu, Yuhui Wei
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Influence of pluronic F68 on oxygen mass transfer
Biotechnology Progress, 2013Pluronic F68 is one of the most used shear protecting additives in cell culture cultivations. It is well known from literature that such surface‐active surfactants lower the surface tension at the gas‐liquid interface, which influences the mass transfer. In this study, the effect of Pluronic F68 on oxygen mass transfer in aqueous solutions was examined.
Christian, Sieblist +2 more
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Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting
Biomedicine and Pharmacotherapy, 2019 Galangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to its poor aqueous solubility, P-gp efflux and rapid in vivo metabolism by cytochrome enzymes.
Varsha Pokharkar +2 more
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Application of Pluronic F68 for Aqueous Two-Phase Extraction of Proteins
Journal of Chemical Engineering of Japan, 1993 Studies were made of the application of a block copolymer of polyethylene oxide and polypropylene oxide, Pluronic F68, to aqueous two-phase extraction of proteins. For Pluronic F68/salt systems, the effects of temperature, salt concentration and pH on the binodials and protein partitioning were studied.
Masamichi Kamihira, Hiroshi Takeuchi
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Effect of pluronic-F68 on the development of tumor metastasis
Cancer, 1972Walker 256 tumor cells were administered intravenously to rats. Treatment with PLF68 decreased the incidence of pulmonary metastasis, probably secondary to its effect on coagulation.
M, Silk, E, Sigman
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Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism
International Journal of Pharmaceutics, 2008The aim of this work was to investigate the effects of pluronic F68 block copolymer on the P-gp-mediated transport of celiprolol (CEL) and CYP3A4-mediated formation of midazolam (MDZ) metabolite 1'-hydroxymidazolam. Over a range from 0.03 to 0.3%, pluronic F68 increased apical-to-basolateral permeability (AP-BL) and decreased basolateral-to-apical ...
Gao Li, Jiangeng Huang, Luqin Si
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