Results 91 to 100 of about 5,618 (207)

Fabrication of Multimodal Anion Exchange Membrane for Chromatographic Purification of Full Adeno‐Associated Viral Capsids

Advanced Materials Interfaces, Volume 12, Issue 22, November 22, 2025.
A novel multi‐modal anion exchange membrane (MMAEX) is successfully fabricated for separating empty and full AAV2 capsids. The functionalized membrane has an average pore size of 0.5 µm and exhibits both charge and hydrophobic functionality. A full capsid recovery of 72.9% at 85.3% purity with gradient elution, or 70.3% recovery at 92.2% purity with ...
Xiaolei Hao, Sumith Ranil Wickramasinghe, Xianghong Qian   +2 more
wiley   +1 more source

Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is an X-linked, fatal muscle wasting disease for which there is currently no cure and limited palliative treatments.
A Franco, AV Kabanov, B Greenebaum, B Mokri, BJ Petrof, C Alvarez-Lorenzo, CF Spurney, CI Wooddell, D Townsend, Dominic J. Wells, EW Yeung, F Muntoni, GJ Broze, Hannah M. Kaneb, JG Quinlan, JH Gu, JM Grindel, JW Burns, JY Wang, K Bushby, M Brockington, N Deconinck, OO Krylova, P Adams-Graves, PS Sharp, R Ng, RC Jewell, RC Lee, Rebecca L. Terry, Ronald Cohn, S Yasuda, SA Maskarinec, T Demina, TJ Burkholder, Y Lai, YC Chen   +35 more
core   +4 more sources

Lecithin‐Modified Nanoscale Oxygen Carriers (LENOX): New Designed Perfluorocarbon‐Based Artificial Oxygen Carriers Ready‐to‐Use in Clinically Relevant Media

Advanced NanoBiomed Research, Volume 5, Issue 11, November 2025.
Perfluorocarbon‐based artificial oxygen carriers have long been of scientific interest for because they can be used as oxygen donors in medical applications. Lecithin‐modified nanoscale oxygen carriers (LENOX) are a newly designed nanoscaled emulsion based on perfluorodecalin, which is characterized by its compatibility with numerous clinically ...
Fabian Nocke, Martin A. Schroer, Marina Penzel, Miriam Cantore, Andrea U. Steinbicker, Katja B. Ferenz   +5 more
wiley   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

Biotechnology Progress, Volume 41, Issue 6, November/December 2025.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao, Ronny Horax, Xianghong Qian, April Wheeler, Hironobu Shirataki, S. Ranil Wickramasinghe   +5 more
wiley   +1 more source

Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations : design, characterisation, toxicity and transcorneal permeation studies [PDF]

, 2017
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-
Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abdelkader, Abou El-elaa, Ajit, Al Khateb, Alany, Almeida, Amal K. Hussein, Angius, Anil Vangala, Asasutjarit, Attama, Auerbach, Baeyens, Baklayan, Baloglu, Chena, Dohle, Dumortier, El-Kamel, Faber, Fathalla, Fernández-Ferreiro, Garg, Gupta, Hao, Heilmann, Kadam, Khaled A. Khaled, Kim, Kim, Law, Li, Ling, Luepke, Mansour, Mayol, Michael Longman, Mosmann, Mythri, Nanjawade, Nanjwadea, Newa, Omar H. El-Garhy, Qi, Raid G. Alany, Riccia, Rooks, Rossi, Rupenthal, Rupenthala, Schoenwald, Sinha, Sintzel, Sunil, Thakor, Thrimawithana, Thrimawithanaa, Vadnere, Verstraelen, Walters, Wei, Weterings, Worakul, Xu, Yang, Zeinab M.A. Fathalla   +72 more
core   +1 more source

FTIR spectra of Pluronics F68, PLGA-PEG, thymoquinone, TQ-PLGA-PF68

, 2021
The pure substances (Pluronics F68, PLGA-PEG, thymoquinone) and TQ-PLGA-PF68 nanoparticles were analyzed using the FT-NIR spectrometer. The acquired spectra were processed using Frontier's Spectrum 10 Software.
openaire   +1 more source

Near‐Infrared‐Triggered Nanodroplets for Imaging‐Guided Macrophage‐Mediated Cancer Immunotherapy

Small Methods, Volume 9, Issue 11, November 24, 2025.
Schematic illustration of the Nanodroplets and their theranostics application–The engineered nanodroplets integrate a multifunctional design, encapsulating the immunostimulant resiquimod (R848), indocyanine green (ICG), and volatile perfluoropentane (PFP), within a biocompatible double‐emulsion structure.
Junxi Yi, Meenakshi Chauhan, Yang Zhao, Yun‐Sheng Chen   +3 more
wiley   +1 more source

Curcuminoid in Nanoemulsion Formulations Cause Enhanced Cell Death in the HeLa Cancer Cell Culture Model [PDF]

, 2015
Purpose: To formulate and characterize curcuminoid (insoluble chemoprevention agent) loaded nanoemulsions and evaluate their cytotoxicity in HeLa ...
Das, Nandita, Das, Sudip, Kheradia, Nikita   +2 more
core   +1 more source

Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels [PDF]

, 2015
The design and application of biomimetic hydrogels have become an important and integral part of modern tissue engineering and regenerative medicine. Many of these hydrogels are prepared from synthetic macromers (e.g., poly(ethylene glycol) or PEG) as ...
Lin, Chien-Chi
core   +1 more source

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

Drug Delivery, 2018
The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug ...
Marzia Cirri, Lavinia Maestrini, Francesca Maestrelli, Natascia Mennini, Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +6 more
doaj   +1 more source