Results 101 to 110 of about 49,031 (291)
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
, 2016 How did we discover the existence of Pluto? Why have we reclassified Pluto as a dwarf planet? What do we know of other dwarf planets? How do we decide if a celestial body is to be classified as a planet or not?
Vallath, Ramgopal (RamG)
core
Dynamical capture in the Pluto-Charon system
, 2012 This paper explores the possibility that the progenitors of the small satellites of Pluto got captured in the Pluto-Charon system from the massive heliocentric planetesimal disk in which Pluto was originally embedded into.
Morbidelli, A. +3 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Changes in a scientific concept: what is a planet? [PDF]
, 2007 The need for an explicit and exact definition of a planet has arise out of the growing rate of discovery of Trans-Neptunian Objects (TNOs) with physical and orbital properties comparable with those of Pluto, the smallest planet of the solar system.
Murzi, Mauro
core
, 2016 Geographies of Pluto is a collection of fourteen essays that consider the relationship between individual consciousness and the cosmological universe. The immediate setting is West Virginia, but an inward, emotional landscape dominates the collection, a ...
Fowler, Amelia
core +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Book review: Inhuman Power: Artificial Intelligence and the Future of Capitalism
Studies of Transition States and SocietiesBook review: Inhuman Power: Artificial Intelligence and the Future of Capitalism by Nick Dyer-Witheford, Atle Mikkola Kjøsen, & James Steinhoff, 2019, Pluto Press.
Sanja Petkovska
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source