Results 41 to 50 of about 6,722 (243)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Timing and Abundance of Clathrate Formation Control Ocean Evolution in Outer Solar System Bodies: Challenges of Maintaining a Thick Ocean within Pluto

The Planetary Science Journal, 2023
Clathrate hydrates may represent a sizable fraction of material within the icy shells of Kuiper Belt objects and icy moons. They influence the chemical and thermal evolution of subsurface oceans by locking volatiles into the ice shell and by providing ...
Samuel W. Courville, Julie C. Castillo-Rogez, Mohit Melwani Daswani, Elodie Gloesener, Mathieu Choukroun, Joseph G. O’Rourke   +5 more
doaj   +1 more source

Dynamics of Pluto

Icarus, 1989
The present study of the Pluto orbit yielded by the LONGSTOP 1B, 100-Myr numerical integration of the outer planets has given attention to the 3:2 resonance in mean motion with Neptune up to degree 2 in eccentricities and inclinations. Confirmations are obtained for both the 19,900-year period longitudinal libration and the 3.78-Myr period libration of
MILANI COMPARETTI, ANDREA, NOBILI, ANNA MARIA, CARPINO M.   +2 more
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Crater Dimensions on the Dwarf Planets

The Planetary Science Journal
The icy dwarf planets of Pluto, Charon, and Ceres provide important geologic comparisons for each other as they possess similar gravities and experience impacts of similar velocities compared to larger planets and moons.
Veronica J. Bray, Michael F. Zeilnhofer, S. J. Robbins, P. M. Schenk, Kelsi M. Singer, O. L. White, S. A. Stern, S. D. Benecchi, K. A. Durfey, H. A. Weaver, C. B. Olkin, J. R. Spencer, the New Horizons Geology and Geophysics Investigation Team   +12 more
doaj   +1 more source

Large-scale cryovolcanic resurfacing on Pluto

Nature Communications, 2022
Giant icy volcanos (cryovolcanos) on Pluto are unique in the imaged solar system and provide evidence for unexpected, active geology late in Pluto’s history.
Kelsi N. Singer, Oliver L. White, Bernard Schmitt, Erika L. Rader, Silvia Protopapa, William M. Grundy, Dale P. Cruikshank, Tanguy Bertrand, Paul M. Schenk, William B. McKinnon, S. Alan Stern, Rajani D. Dhingra, Kirby D. Runyon, Ross A. Beyer, Veronica J. Bray, Cristina Dalle Ore, John R. Spencer, Jeffrey M. Moore, Francis Nimmo, James T. Keane, Leslie A. Young, Catherine B. Olkin, Tod R. Lauer, Harold A. Weaver, Kimberly Ennico-Smith   +24 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Dunes on Pluto

Science, 2018
Methane ice dunes on Pluto Wind-blown sand or ice dunes are known on Earth, Mars, Venus, Titan, and comet 67P/Churyumov-Gerasimenko. Telfer et al. used images taken by the New Horizons spacecraft to identify dunes in the Sputnik Planitia region on Pluto (see the Perspective by Hayes).
Matt W. Telfer, Eric J. R. Parteli, Jani Radebaugh, Ross A. Beyer, Tanguy Bertrand, François Forget, Francis Nimmo, Will M. Grundy, Jeffrey M. Moore, S. Alan Stern, John Spencer, Tod R. Lauer, Alissa M. Earle, Richard P. Binzel, Hal A. Weaver, Cathy B. Olkin, Leslie A. Young, Kimberly Ennico, Kirby Runyon, Marc Buie, Bonnie Buratti, Andy Cheng, J.J. Kavelaars, Ivan Linscott, William B. McKinnon, Harold Reitsema, Dennis Reuter, Paul Schenk, Mark Showalter, Len Tyler   +29 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pluto's Antipodal Terrains Imply a Thick Subsurface Ocean and Hydrated Core

Geophysical Research Letters, 2021
Recent analysis of New Horizons data revealed an ∼1,000‐km‐diameter region of large‐scale lineations antipodal to Sputnik Planitia, the 1,200 × 2,000 km elliptical impact basin on Pluto's anti‐Charon hemisphere.
C. Adeene Denton, Brandon C. Johnson, Shigeru Wakita, Andrew M. Freed, H. Jay Melosh, S. Alan Stern   +5 more
doaj   +1 more source