Results 191 to 200 of about 46,684 (307)

The Pineal Gland Is Required for Optimal Nighttime Immunity to Bacterial Infection in Larval Zebrafish

open access: yesJournal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT The immune response to bacterial infection demonstrates circadian rhythmicity, with heightened antibacterial immunity often observed during the daytime. This circadian‐gated immune response is believed to have evolved to synchronize peak antibacterial immunity with the increased threat of infection when active.
Gabriel Anasarias‐Dumo   +6 more
wiley   +1 more source

Black flesh disorder in mango: a chilling injury symptom increased by early harvest and low storage temperature and reduced by 1‐methylcyclopropene

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6508-6522, 30 August 2026.
Abstract BACKGROUND Black flesh (BF) is an internal disorder in mango, characterized by the development of dark brown to black pigmentation in the inner mesocarp tissue during storage or transport. This study investigated the effects of harvest maturity, low storage or low transport temperatures, and 1‐methylcyclopropene (1‐MCP) on mango fruit ...
Bruna Parente de Carvalho Pires   +8 more
wiley   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

open access: yesJournal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala   +2 more
wiley   +1 more source

Low Failure Rates and Favorable Outcomes of Meniscal Repair With Concomitant Anterior Cruciate Ligament Primary Repair at Minimum 2-Year Follow-up. [PDF]

open access: yesOrthop J Sports Med
Mueller MM   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, Volume 20, Issue 8, Page 2054-2084, August 2026.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Predicting End-Use Quality in Russet Potatoes Through Biochemical and Starch Analysis. [PDF]

open access: yesJ Food Sci
Lavhale SG   +7 more
europepmc   +1 more source

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