Results 181 to 190 of about 46,684 (307)

Conformational diversity in poly‐HAMP arrays and its implications for signal transduction

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract Prokaryotic transmembrane receptors are built around a helical coiled‐coil backbone, with sensory, modulatory, and effector domains arranged along its length. The modulatory HAMP domain forms a parallel four‐helix coiled coil integrated into this backbone, typically connecting transmembrane segments with downstream cytosolic domains.
Murray Coles   +8 more
wiley   +1 more source

The Use of Piperidinium Surfactants in Nematicide Formulations. [PDF]

open access: yesMolecules
Kushnazarova R   +6 more
europepmc   +1 more source

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Harshita Sawdekar   +6 more
wiley   +1 more source

Structure and conformational dynamics of the Pseudomonas CbrA transceptor

open access: yesProtein Science, Volume 35, Issue 9, September 2026.
Abstract The CbrA protein is a central regulator of carbon metabolism, biofilm formation, and virulence in Pseudomonas species, but the molecular mechanisms by which CbrA links nutrient sensing to downstream signaling has remained unclear. CbrA is a rare “transceptor” that combines membrane transporter and histidine kinase domains into a single ...
Melanie A. Orlando   +4 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah   +7 more
wiley   +1 more source

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