Results 181 to 190 of about 74,938 (343)

La PME tunisienne

, 2022
Denieuil, Pierre-Noël, Denieuil, Pierre-Noël > Auteur, B'chir, Abdelkhalek > Auteur   +2 more
openaire   +1 more source

Office 2024 Professional Plus para PME em Portugal — Guia de Licenciamento

Joao Ferreira
openalex   +1 more source

Digitalisation des pratiques de gestion, formalisation et performance financière des PME à Butembo : rôle médiateur de l’accès au financement et portée émergente de l’intelligence artificielle [PDF]

Mumbere Katswavi Junior
openalex   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Precomputed grid potential (PGP) method: Exact reciprocal-space acceleration of particle mesh Ewald for Monte Carlo simulations. [PDF]

J Chem Phys
Zhao M, Yu W, MacKerell AD.
europepmc   +1 more source

Digitalisation, intelligence artificielle et transformation des PME africaines : formalisation, financement et performance dans le contexte congolais [PDF]

Mumbere Katswavi Junior
openalex   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Integrated Transcriptomic, Enzymatic, and Immunolocalization Analysis Reveals Pectin Remodeling-Mediated Defense Against <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> Race 4 in Banana. [PDF]

Curr Issues Mol Biol
Sharif R, Xing Y, Song H, Cao H, Li Y, Liu W, Zhan H, Xu C.   +7 more
europepmc   +1 more source

A EXPANSÃO E GARANTIA DO DIREITO À EDUCAÇÃO: DO PNE AOS PMES NO ESTADO DO PIAUÍ

Maria Isabela Val de Oliveira, Fabrícia Pereira Teles   +1 more
openalex   +2 more sources

Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan‐to‐heme energy transfer facilitates lignin degradation in ClassII peroxidases

The FEBS Journal, EarlyView.
In lignin peroxidase and versatile peroxidase, low FRET from buried Trp to heme promotes long‐range electron transfer (LRET) from substrate to heme. This efficient electron flow is facilitated by reduced FRET competition. This mechanism likely evolved to enable the effective degradation of bulky, high‐redox‐potential lignin that cannot reach the enzyme'
Yi Ren, Dale Ang, Haluk Ertan, Anne Poljak, Janice R. Aldrich‐Wright, Wallace J. Bridge, Khawar Sohail Siddiqui   +6 more
wiley   +1 more source