Results 201 to 210 of about 46,684 (307)

Cortisol Recognition by a Conformationally Responsive DNA Aptamer

open access: yesAdvanced Sensor Research, Volume 5, Issue 8, August 2026.
The full‐length 85mer cortisol aptamer intrinsically populates two metastable conformational states in equilibrium. Cortisol binding redistributes the conformational ensemble by shifting the equilibrium between open and compact states while maintaining the underlying secondary structure. This ligand‐induced tertiary reorganization provides an atomistic
Lakshitha Jasin Arachchige   +4 more
wiley   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

open access: yesAdvanced Science, Volume 13, Issue 44, 7 August 2026.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen   +11 more
wiley   +1 more source

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

open access: yesAdvanced Science, Volume 13, Issue 44, 7 August 2026.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang   +5 more
wiley   +1 more source

Tuning Steric Hindrance and Intermolecular Interactions in Tetrahydroindolocarbazoles for Dual Thermally Activated Delayed Fluorescence and Room‐Temperature Phosphorescence

open access: yesChemistryEurope, Volume 4, Issue 8, August 2026.
Tuning steric hindrance and intermolecular interactions in tetrahydroindolocarbazoles (ICZ) enables ultralong organic phosphorescence (UOP) and dual thermally activated delayed fluorescence‐room‐temperature phosphorescence (TADF‐RTP). Alkyl and polyether chain modifications dramatically enhance luminescence lifetimes, achieving persistent emission ...
Nagham Ibrahim   +3 more
wiley   +1 more source

Integrative multi‐omics analysis prioritizes DPEP1 as a genetically supported candidate associated with skin cancer risk

open access: yesClinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Flowchart of the study design outlining target identification, validation, and subsequent functional and translational characterization. Abstract Background Skin cancer (SC) is among the most prevalent malignancies, yet causal circulating proteins and tractable therapeutic targets remain poorly defined.
Fan Shen   +7 more
wiley   +1 more source

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