Results 31 to 40 of about 46,684 (307)

O PROGRAMA MAIS EDUCAÇÃO (PME) NO MUNICÍPIO DE BELTERRA/PA: PERCEPÇÃO DA EQUIPE GESTORA

Linguagens, Educação e Sociedade, 2018
O presente artigo objetiva analisar a implementação do Programa Mais Educação (PME) na perspectiva da equipe gestora de uma escola municipal de Belterra/PA. O PME teve como foco a reorganização curricular mediante a ampliação da jornada escolar no ensino
LILIA TRAVASSOS SOUSA, MARIA LILIA IMBIRIBA SOUSA COLARES   +1 more
doaj   +1 more source

Étude de l’influence des facteurs de la croissance des PME au Sénégal

Revue Marocaine de l'Entrepreneuriat, de l'Innovation et du Management, 2017
Au Sénégal, pour parler de l’entrepreneuriat il faut se référer à un certain nombre de mesures connues, mais les enrichir d’éléments culturels, politiques et structurels qui colorent singulièrement les expériences et les potentialités.
Mazi Gilles Christ GARAGBA
doaj   +1 more source

Characterization and Transcript Profiling of PME and PMEI Gene Families during Peach Fruit Maturation

, 2017
A BSTRACT . Pectins are synthesized and secreted to the cell wall as highly methyl-esterified polymers and demethyl- esterified by pectin methylesterases (PMEs), which are regulated by pectin methylesterase inhibitors (PMEIs).
Yunqin Zhu, Wenfang Zeng, Xiaobei Wang, Lei Pan, Liang Niu, Zhenhua Lu, Guochao Cui, Zhiqiang Wang   +7 more
semanticscholar   +1 more source

Characterization of the Tomato (Solanum lycopersicum) Pectin Methylesterases: Evolution, Activity of Isoforms and Expression During Fruit Ripening

Frontiers in Plant Science, 2020
Pectin methylesterase (PME, EC 3.1.1.11) is a hydrolytic enzyme of pectin that plays multiple roles in different plant development processes and responses to biotic stress. To characterize the molecular evolution and functional divergence of the PME gene
Bo Wen, Feng Zhang, Xiaozhen Wu, Huan Li
doaj   +1 more source

AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells

OncoTargets and Therapy, 2016
Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is widely used for medicinal purposes in many Asian countries due to its various bioactivities. A series of AA derivatives has been synthesized in attempts to improve its therapeutic potencies.
Yue Jing, G. Wang, Ying Ge, Minjie Xu, Shuainan Tang, Zhunan Gong   +5 more
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling

Cell Death Discovery, 2023
Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens, Rita Derua, Veerle Janssens   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Clinical phenotype features and genetic etiologies of 38 children with progressive myoclonic epilepsy

Acta Epileptologica, 2020
Background Progressive myoclonic epilepsy (PME) is a group of neurodegenerative diseases with genetic heterogeneity and phenotypic similarities, and many cases remain unknown of the genetic causes. This study is aim to summarize the clinical features and
Jing Zhang, Ying Yang, Xueyang Niu, Jiaoyang Chen, Wei Sun, Changhong Ding, Lifang Dai, Liping Zhang, Qi Zeng, Yi Chen, Xiaojuan Tian, Xiaoling Yang, Taoyun Ji, Zhixian Yang, Yanling Yang, Yuwu Jiang, Yuehua Zhang   +16 more
doaj   +1 more source

Cytotoxic effects of parijoto (Medinilla speciosa Reinw. Ex. Bl.) methanol extract combined with cisplatin on WiDr colon cancer cells through apoptosis induction

Indonesian Journal of Biotechnology, 2022
Parijoto (Medinilla speciosa Reinw. Ex. Bl.) is a medicinal plant with cytotoxic effects on cancer cells in vitro. As only a limited number of studies have reported the effect of parijoto on colon cancer cells, this study initially aimed to measure the ...
Anif Nur Artanti, Fea Prihapsara, Ranita Kumalasari Susanto   +2 more
doaj   +1 more source