Results 21 to 30 of about 42,121 (225)

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications.
Ball, V, Betts, C A, Gait, M J, Godfrey, C, Hammond, S M, Healicon, R, Manzano, R, McClorey, G, Merritt, T M, Muses, S, O'Donovan, L, Tyler, D, Wells, D J, Wells, K E, Westering, T, Wood, M J   +15 more
core   +3 more sources

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Molecular Therapy: Nucleic Acids, 2013
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of ...
HaiFang Yin, Prisca Boisguerin, Hong M Moulton, Corinne Betts, Yiqi Seow, Jordan Boutilier, Qingsong Wang, Anthony Walsh, Bernard Lebleu, Matthew JA Wood   +9 more
doaj   +1 more source

Phosphomolybdic Acid coupling with Vulcan XC72 Carbon as Superior Catalyst to Enhance ORR Activity and Performance of MFC

International Journal of Electrochemical Science, 2019
Microbial fuel cell (MFC) is an emerging technology that can treat wastewater and recover energy simultaneously However, there are many factors that limit its application, among which cathode catalysts are one of the main obstacles.
Kai Zhang, Yongkui Huang, Daijun Zhang, Aqiang Ding, Xiaoting Zhang, Peili Lu   +5 more
doaj   +1 more source

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

Molecular Therapy: Nucleic Acids, 2019
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials. However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery
Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu   +4 more
doaj   +1 more source

Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics

Journal of Materials Science: Materials in Medicine, 2023
Glioma is the most common malignant tumor of the brain and enhancing the efficacy of chemotherapy in glioma is critical for improving patients’ prognosis.
Min Dong, Ying Liu, Biao Liu, Jin Peng, Yuxia Tang, Guangming Lu, Haibin Shi, Feipeng Zhu   +7 more
doaj   +1 more source

Association of ESR1 polymorphism rs2234693 and rs9340799 with postmenopausal osteoporosis in a Chinese population

BMC Musculoskeletal Disorders, 2020
Background Postmenopausal osteoporosis (PMO) is the most common type of primary osteoporosis. ESR1 polymorphism rs2234693 and rs9340799 has been widely studied as a candidate gene associated with PMO, however, the findings were inconclusive.
Jin Shu, Junling Li, Yujuan Fu, Xuelian Hui, Yani Jin, Mengjie Chen, Xin Zheng, Yaowu Shi   +7 more
doaj   +1 more source

Barriers to Effective Postmenopausal Osteoporosis Treatment: A Qualitative Study of Patients' and Practitioners' Views. [PDF]

PLoS ONE, 2016
Only a minority of patients at high risk for osteoporotic fracture receive treatment.Study patients' and physicians' views regarding postmenopausal osteoporosis (PMO) to identify impediments to good care.A qualitative study involving 18 physicians and 37
Sophie Alami, Lucile Hervouet, Serge Poiraudeau, Karine Briot, Christian Roux   +4 more
doaj   +1 more source

Planktonic and sediment-associated aerobic methanotrophs in two seep systems along the North American margin [PDF]

, 2008
Methane vents are of significant geochemical and ecological importance. Notable progress has been made towards understanding anaerobic methane oxidation in marine sediments, however, the diversity and distribution of aerobic methanotrophs in the water ...
Orphan, Victoria J., Tavormina, Patricia L., Ussler, William, III   +2 more
core   +4 more sources

Uma visão do VI Congresso Brasileiro de Gerenciamento de Projetos

Navus: Revista de Gestão e Tecnologia, 2012
Este trabalho relata uma visão do VI CONGRESSO BRASILEIRO DE GERENCIAMENTO DE PROJETOS & III FÓRUM INTERNACIONAL DE GOVERNO, destacando os pontos principais dos assuntos debatidos.
Helio Aisenberg Ferenhof
doaj   +1 more source

Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting [PDF]

, 2008
Morbidity following CABG (coronary artery bypass grafting) is difficult to predict and leads to increased healthcare costs. We hypothesized that pre-operative CMR (cardiac magnetic resonance) findings would predict resource utilization in elective CABG ...
Alfakih, American Heart Association, Anna F. Dominiczak, Baks, Bellenger, Berry, Berry, British Heart Foundation Heart Statistics, Christian Delles, Colin Berry, Eisenberg, Ferguson, Fieno, Geissler, Geoffrey A. Berg, Gibbons, Hein, Henry J. Dargie, Higgins, Higgins, Hombach, John E. Foster, Lassnigg, Lorenz, Lukas U. Zimmerli, Lund, Mark, Michalopoulos, Mosteller, Mounsey, Nathanson, Pell, Pennell, Roques, Rosamond, Schvartzman, Selvanayagam, Sievers, Simonetti, Tracey Steedman, Tu, Tu, Zimmerli   +42 more
core   +1 more source