Results 1 to 10 of about 107,048 (164)

External Validation of Nomograms for Predicting Pelvic Lymph Node Metastases in Patients with Prostate Cancer and the Added Value of the Prostate-specific Membrane Antigen Positron Emission Tomography–based PRIMARY Score [PDF]

European Urology Open Science
Background and objective: The aim of our study was to predict pathological lymph node involvement (stage pN1) in patients undergoing radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND) for prostate cancer (PC) and to compare the ...
Muhammet Demirbilek, Göktuğ Kalender, Said Bıyıkoglu, Sertaç Asa, Emre Akkuş, İclal Gürses, Levent Kabasakal, Bülent Önal   +7 more
doaj   +2 more sources

Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model [PDF]

Frontiers in Immunology
Childhood vaccination provides protection against infectious diseases, but multiple vaccinations are required to achieve this. In situations like influenza epidemics or COVID-19 pandemic, vaccine demands may exceed production capacity, highlighting the ...
Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Gabriel Kristian Pedersen, Dennis Christensen, Serena Marchi, Emanuele Montomoli, Emanuele Montomoli, Stefanía P. Bjarnarson, Stefanía P. Bjarnarson, Ingileif Jonsdottir, Ingileif Jonsdottir, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind   +14 more
doaj   +2 more sources

Correlation between clinical and pathological nodal status in hepatocellular carcinoma: identifying risk factors for lymph node metastasis via the national cancer database [PDF]

World Journal of Surgical Oncology
Background Lymph node metastasis (LNM) in hepatocellular carcinoma (HCC) is associated with significantly worse prognosis, yet its detection and risk stratification remain challenging in clinical practice.
Huisong Lee, Kyunguk Jung, Michael Luu, Kambiz Kosari, Nicholas Nissen, Ju Dong Yang   +5 more
doaj   +2 more sources

Anatomical distribution of disease in pN1 prostate cancer with BCR post‐RP: A PSMA‐PET/CT‐based analysis [PDF]

BJUI Compass
Objectives To explore the distribution of metastatic disease in pN1 patients with biochemical recurrence (BCR) assessed by Prostate‐Specific Membrane Antigen‐Positron‐Emission/Computed Tomography (PSMA‐PET/CT).
Lotte G. Zuur, Katelijne C. C. deBie, Lieke Wever, Anne‐Claire Berrens, Jean‐Paul A. vanBasten, Harm H. E. vanMelick, Maarten L. Donswijk, Daniela E. Oprea‐Lager, Wouter V. Vogel, Henk G. van derPoel, André N. Vis, Pim J. vanLeeuwen   +11 more
doaj   +2 more sources

Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph‐node invasion [PDF]

Clinical and Translational Medicine
Background Nomograms or comparable techniques can be used to determine which patients with prostate cancer (PCa) will benefit from extended pelvic lymph node dissection (ePLND).
Matias A. Bustos, Kelly K. Chong, Yoko Koh, SooMin Kim, Eleanor Ziarnik, Romela I. Ramos, Gianna Jimenez, David L. Krasne, Warren M. Allen, Timothy G. Wilson, Dave S. B. Hoon   +10 more
doaj   +2 more sources

Prognostic Stratification of pN1 Prostate Cancer After Radical Prostatectomy: A Competing Risk Analysis from a Multi-institutional Cohort [PDF]

European Urology Open Science
Background and objective: Lymph node–positive (pN1) prostate cancer (PCa) is a heterogeneous disease, and a clear definition of prognostic groups is urgently needed.
Alexander Giesen, Daimantas Milonas, Annouschka Laenen, Lorenzo Tosco, Piotr Chlosta, Gert De Meerleer, Gaëtan Devos, Wouter Everaerts, Markus Graefen, Christian Gratzke, Giansilvio Marchioro, Rafael Sanchez-Salas, Bertrand Tombal, Henk Van Der Poel, Hendrik Van Poppel, Zilvinas Venclovas, Alberto Briganti, Paolo Gontero, Jeffrey R. Karnes, Martin Spahn, Steven Joniau   +20 more
doaj   +2 more sources

DNA-methylation and genomic copy number in primary tumors and corresponding lymph node metastases in prostate cancer from patients with low and high Gleason score

Clinical and Translational Radiation Oncology, 2023
Purpose: In prostate cancer, the indication to irradiate the pelvic lymphatic pathways in clinical node-negative patients is solely based on clinical nomograms.
Kristian Unger, Julia Hess, Vera Link, Alexander Buchner, Chukwuka Eze, Minglun Li, Christian Stief, Thomas Kirchner, Frederick Klauschen, Horst Zitzelsberger, Maximilian Niyazi, Ute Ganswindt, Nina-Sophie Schmidt-Hegemann, Claus Belka   +13 more
doaj   +1 more source

The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice

Frontiers in Immunology, 2023
Immaturity of the neonatal immune system contributes to increased susceptibility to infectious diseases and poor vaccine responses. Therefore, better strategies for early life vaccination are needed.
Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind, Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Ingileif Jonsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson, Stefania P. Bjarnarson   +9 more
doaj   +1 more source

Predicting the probability of pT3 or higher pathological stage at radical prostatectomy: COVID19-specific considerations

Frontiers in Oncology, 2022
BackgroundWe tested whether a model identifying prostate cancer (PCa) patients at risk of pT3-4/pN1 can be developed for use during COVID19 pandemic, in order to guarantee appropriate treatment to patients harboring advanced disease patients without ...
Luigi Nocera, Luigi Nocera, Lara F. Stolzenbach, Lara F. Stolzenbach, Claudia Collà Ruvolo, Claudia Collà Ruvolo, Mike Wenzel, Mike Wenzel, Christoph Wurnschimmel, Christoph Wurnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Vincenzo Mirone, Felix K. H. Chun, Shahrokh F. Shariat, Shahrokh F. Shariat, Shahrokh F. Shariat, Shahrokh F. Shariat, Shahrokh F. Shariat, Shahrokh F. Shariat, Markus Graefen, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I. Karakiewicz   +25 more
doaj   +1 more source

Neutrophil-to-lymphocyte ratio predicts nodal involvement in unfavourable, clinically nonmetastatic prostate cancer patients and overall survival in pN1 patients

Scientific Reports, 2023
The aim of our study was to determine the clinical utility of neutrophil-to-lymphocyte ratio (NLR) in predicting presence and prognosis of nodal involvement in patients treated with radical prostatectomy (RP) due to prostate cancer.
Piotr Zapała, Karolina Garbas, Zbigniew Lewandowski, Aleksander Ślusarczyk, Cezary Ślusarczyk, Łukasz Mielczarek, Giancarlo Marra, Benjamin Pradere, Pawel Rajwa, Łukasz Zapała, Piotr Radziszewski   +10 more
doaj   +1 more source