Results 101 to 110 of about 133,257 (324)
Advanced Science, EarlyView.TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen +16 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
Estradiol resolves pneumonia via ERβ in regulatory T cells
JCI Insight, 2021 Current treatments for pneumonia (PNA) are focused on the pathogens. Mortality from PNA-induced acute lung injury (PNA-ALI) remains high, underscoring the need for additional therapeutic targets.
Ye Xiong +7 more
doaj +1 more source
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin +3 more
core +3 more sources
Nucleic Acids Research, 2015 PNA is a promising molecule for antisense therapy of trinucleotide repeat disorders. We present the first crystal structures of RNA–PNA duplexes. They contain CUG repeats, relevant to myotonic dystrophy type I, and CAG repeats associated with poly ...
A. Kiliszek +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng +27 more
wiley +1 more source
Automated Detection of Point Mutations by Electrophoresis in Peptide-Nucleic Acid-Containing Gels
BioTechniques, 1999 Polymerization of electronically, essentially neutral peptide nucleic acids (PNA) into polyacrylamide gels creates a medium in which the salt-independent properties of PNA/DNA interactions are used to achieve hybridization with target DNA during affinity
Gabor L. Igloi
doaj +1 more source
Extending the Coordination of Cognitive and Social Perspectives [PDF]
, 2012 Cognitive analyses are typically used to study individuals, whereas social analyses are typically used to study groups. In this article, I make a distinction between what one is looking with?one’s theoretical lens?and what one is looking at?e.g., an ...
Simon, Martin A.
core +2 more sources
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, EarlyView.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Proceedings of the National Academy of Sciences, 2003 The Proceedings will … serve as a medium for the prompt publication of brief original papers by members of the Academy and other American investigators. Its aim will be to furnish a comprehensive survey of the more important results of … scientific research . . . . .
openaire +2 more sources