Results 91 to 100 of about 51,393 (251)

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

Molecular Therapy: Nucleic Acids, 2016
Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health.
Zhengyang Zeng, Shisong Han, Wei Hong, Yange Lang, Fangfang Li, Yongxiang Liu, Zeyong Li, Yingliang Wu, Wenxin Li, Xianzheng Zhang, Zhijian Cao   +10 more
doaj   +1 more source

PNA technology

, 2002
Peptide nucleic acids (PNA) were originally conceived and designed as sequence-specific DNA binding reagents targeting the DNA major groove in analogy to triplex-forming oligonucleotides.
Nielsen, Peter Eigil, Nielsen, Peter E.
core   +1 more source

Experimental methods in chemical engineering: The scientific method versus engineering design methodology

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Engineering graduate students confuse the scientific method and problem solving when presenting their pre‐doctoral exams and theses: Science discourse adopts question and hypotheses to assert and establish a study's rationale, while it is problem and objectives in engineering design.
Gregory S. Patience, Alexander R. P. Harrison, Nicolas A. Patience, Paul A. Patience, Robert S. Weber   +4 more
wiley   +1 more source

Staining patterns of PNA and UEA-I lectins in the postnatal developing male genital excurrent duct epithelium in mice

Journal of Advanced Veterinary and Animal Research
Objectives: The research was aimed at determining the staining patterns of Peanut agglutinin (PNA) lectin and Ulex europaeus agglutinin I (UEA-I) lectin in postnatal developing (day 1 to 8 weeks) male genital excurrent duct epithelium in mice.
Md. Royhan Gofur, Kazushige Ogawa
doaj   +1 more source

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Frontiers in Microbiology, 2019
Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding ...
Lise Goltermann, Niloofar Yavari, Meiqin Zhang, Anubrata Ghosal, Peter E. Nielsen   +4 more
doaj   +1 more source

Synthesis of Pyrrolidinone PNA:  A Novel Conformationally Restricted PNA Analogue

, 2016
To preorganize PNA for duplex formation, a new cyclic pyrrolidinone PNA analogue has been designed. In this analogue the aminoethylglycine backbone and the methylenecarbonyl linker are connected, introducing two chiral centers compared to PNA.
Thomas Boesen (57139), Guido Zuccarello (3019770), Ask Püschl (3026259), Stefan Pitsch (30694), Peter E. Nielsen (8833), Otto Dahl (3001782)   +5 more
core   +1 more source

Polyoxometalates in Photocatalytic CO2 Reduction: Multielectron Redox Regulation Across Molecular and Hybrid Architectures

EcoEnergy, EarlyView.
This review focuses on multielectron redox regulation across molecular and hybrid architectures for photocatalytic CO2 reduction, covering intrinsic POM photocatalysts, photosensitizer‐assisted assemblies, POM–metal–organic complexes, and POM‐integrated semiconductors and MOF/COF heterostructures to link structural motifs with charge transport, product
Bonan Li, Xiaowen Ruan, Sai Kishore Ravi
wiley   +1 more source

Therapeutic and diagnostic applications of antisense peptide nucleic acids

Molecular Therapy: Nucleic Acids
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland, Madeline Kravitz, Anisha Gupta   +2 more
doaj   +1 more source

Dimensional Engineering of Wet‐Spun MOF‐Based Woven Fabrics for Superior Electromagnetic Wave Absorption

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work fabricated MOF‐based woven absorbing fabrics with dimensional engineering via a wet spinning strategy. The absorbing fabrics achieve a reflection loss of −51.47 dB at 2.9 mm, with an effective absorption bandwidth reaching 3.54 GHz. The absorbing fabrics can be freely bent, stretched, and folded, with individual fibers exhibiting a break ...
Zihao Yan, Liyuan Guan, Qing Liu, Junhao Lin, Jianyong Yu, Bin Ding, Zhaoling Li   +6 more
wiley   +1 more source