Results 81 to 90 of about 51,393 (251)
Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA) [PDF]
, 2003 New PNA analogues derived from aminoethylpyrrolidin- 5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified ...
Ganesh, Krishna N., Sharma, Nagendra K.
core +2 more sources
Preparation Of Clickable Monomers Compatible With Automated PNA Synthesis
, 2019 Peptide nucleic acids (PNA) are artificially synthesized monomers or polymers that mimic DNA or RNA sequences.[1,2] Due to their stability in biological conditions and their ability to bind complementary to DNA or RNA, PNAs have potential medicinal value
Newell, Grace
core
PNA bearing 5-azidomethyluracil: a novel approach for solid and solution phase modification
, 2012 Fmoc- and Boc-protected modified monomers bearing 5-azidomethyluracil nucleobase were synthesized. Four different solid-phase synthetic strategies were tested in order to evaluate the application of these series of monomers for the solid-phase ...
MARCHELLI, Rosangela +5 more
core +1 more source
, 2013 The 2-(o-nitrophenyl)-propyl (NPP) group is used as caging group to mask the nucleobases adenine and cytosine in N-(2-aminoethyl)glycine peptide nucleic acids (aeg-PNA).
Goericke, Bjoern +7 more
core +1 more source
Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.Purpose To evaluate the rate of matrix‐induced autologous chondrocyte implantation (MACI) after cartilage biopsy in a military population. Methods A retrospective review was conducted of all patients who underwent a cartilage biopsy at 2 large regional military health centers between January 2021 and May 2023.
Ryan M. Sanborn +5 more
wiley +1 more source
Thermodynamic Studies on PNA and PNA/DNA Dendrimer Formation
, 2007 In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system
MUSUMECI, DOMENICA +6 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber +15 more
wiley +1 more source
Synthesis and Incorporation into PNA of Fluorinated Olefinic PNA (F-OPA) Monomers
, 2003 A fluorinated OPA monomer containing the base thymine ((Z)-t-F-OPA) was synthesized in 12 steps, featuring a highly selective allylic over homoallylic Mitsunobu substitution for the introduction of the nucleobase.
Leumann, Christian
core
, 2004 Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with ...
Nielsen, Peter E.
core +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source